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protein coding gene - trz1 (SPAC1D4.10) - tRNAse Z, nuclear 3'-tRNA processing endonuclease Trz1

Gene summary

Standard name
trz1
Systematic ID
SPAC1D4.10
Product
tRNAse Z, nuclear 3'-tRNA processing endonuclease Trz1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sptrz1
UniProt ID
Q10155
ORFeome ID
28/28H01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 653519..656657 forward strand

Annotation

Complementation

PBO:0000514 - functionally complemented by S. cerevisiae YKR079C

References:

Disease association

MONDO:0014190 - combined oxidative phosphorylation defect type 17

References:

MONDO:0013872 - prostate cancer, hereditary, 2

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GO biological process

GO:0042780 - tRNA 3'-end processing

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0042781 - 3'-tRNA processing endoribonuclease activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001528 - nuclear_localization_signal

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000664 - abolished catalytic activity

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002581 - increased level of nuclear tRNA processing intermediates with 3' extensions

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Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0000660 - normal catalytic activity

References:

Genotypes:

FYPO:0002586 - normal mitochondrial tRNA 3'-end processing

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Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0000783 - protein mislocalized to cytoplasm during vegetative growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13691Lactamase_B_4tRNase_Z_domPfam
PF23023Anti-Pycsar_Apyc1Pfam
cd07718RNaseZ_ELAC1_ELAC2-C-term-like_MBL-foldCDD
G3DSA:3.60.15.10RibonucZ/Hydroxyglut_hydroCATH-Gene3D
SSF56281RibonucZ/Hydroxyglut_hydroSUPERFAMILY
PTHR12553RNZ2-likePANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity

Orthologs

References / Literature

PMID:27902423 - Characterization of cis -elements in the promoter of trz2 encoding Schizosaccharomyces pombe mitochondrial tRNA 3'-end processing enzyme.
Liu J et al. Microbiology (Reading) 2017 Jan;163(1):75-85
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21208191 - The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria.
Gan X et al. Biochem J 2011 Apr 01;435(1):103-11
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23928301 - Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe.
Zhang X et al. J Biol Chem 2013 Sep 20;288(38):27415-27422
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:19555350 - Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans.
Zhao Z et al. Biochem J 2009 Aug 27;422(3):483-92
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623