protein coding gene - rad15 (SPAC1D4.12) - transcription factor TFIIH complex DNA helicase (human ERCC2) subunit Rad15

Gene summary

Standard name

rad15

Systematic ID

SPAC1D4.12

Product

transcription factor TFIIH complex DNA helicase (human ERCC2) subunit Rad15

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rhp3, rad5

UniProt ID

P26659

ORFeome ID

38/38C06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 664348..667647 forward strand

Annotation

Protein features

Orthologs

• ERCC2 (HGNC:3434) Homo sapiens
• rad15 (SJAG_00995) Schizosaccharomyces japonicus
• RAD3 (YER171W) Saccharomyces cerevisiae

References / Literature

PMID:166019 - Genetic control of radiation sensitivity in Schizosaccharomyces pombe.

Nasim A et al. Genetics 1975 Apr;79(4):573-82

PMID:1319571 - Cloning and characterisation of the S. pombe rad15 gene, a homologue to the S. cerevisiae RAD3 and human ERCC2 genes.

Murray JM et al. Nucleic Acids Res 1992 Jun 11;20(11):2673-8

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:1534406 - The Schizosaccharomyces pombe rhp3+ gene required for DNA repair and cell viability is functionally interchangeable with the RAD3 gene of Saccharomyces cerevisiae.

Reynolds PR et al. Nucleic Acids Res 1992 May 11;20(9):2327-34

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.

Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9

PMID:9487130 - Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.

Dahlen M et al. Mol Biol Cell 1998 Mar;9(3):611-21

PB_REF:0000003 - Disease Association Curation

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22313747 - A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.

Ukimori S et al. Biosci Biotechnol Biochem 2012;76(2):264-9

PMID:9658208 - Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.

Perego P et al. Mol Pharmacol 1998 Jul;54(1):213-9

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.

Li Y et al. Science 1994 Feb 11;263(5148):805-7

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

InterPro:IPR013020 - Unknown title

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:7623848 - An alternative eukaryotic DNA excision repair pathway.

Freyer GA et al. Mol Cell Biol 1995 Aug;15(8):4572-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:7254221 - Spontaneous and UV-induced recombination in radiation-sensitive mutants of Schizosaccharomyces pombe.

Grossenbacher-Grunder AM et al. Mutat Res 1981 Mar;81(1):37-48

GO_REF:0000002 - Comments