protein coding gene - byr1 (SPAC1D4.13) - MAP kinase kinase Byr1

Gene summary

Standard name

byr1

Systematic ID

SPAC1D4.13

Product

MAP kinase kinase Byr1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ste1, ste3

UniProt ID

P10506

ORFeome ID

15/15C10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 668004..669742 forward strand

Annotation

Protein features

Orthologs

• MAP2K1 (HGNC:6840) Homo sapiens
• MAP2K2 (HGNC:6842) Homo sapiens
• byr1 (SJAG_00993) Schizosaccharomyces japonicus
• STE7 (YDL159W) Saccharomyces cerevisiae

References / Literature

PMID:7791776 - Characterization of fus1 of Schizosaccharomyces pombe: a developmentally controlled function needed for conjugation.

Petersen J et al. Mol Cell Biol 1995 Jul;15(7):3697-707

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.

Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:14665462 - Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.

Tanabe K et al. Eukaryot Cell 2003 Dec;2(6):1274-87

PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.

Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:3042386 - A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

Nadin-Davis SA et al. EMBO J 1988 Apr;7(4):985-93

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:9660817 - Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast.

Yang P et al. J Biol Chem 1998 Jul 17;273(29):18481-9

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:8557102 - Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

Kato T et al. FEBS Lett 1996 Jan 15;378(3):207-12

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:8816472 - Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Barr MM et al. Mol Cell Biol 1996 Oct;16(10):5597-603

PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.

Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483

PMID:1515675 - A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Biol Cell 1992 Jul;3(7):721-34

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24

PMID:2046669 - byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

Wang Y et al. Mol Cell Biol 1991 Jul;11(7):3554-63

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.

Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:8413241 - Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase.

Gotoh Y et al. Mol Cell Biol 1993 Oct;13(10):6427-34

PMID:9133664 - The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.

Hakuno F et al. Genes Cells 1996 Mar;1(3):303-15

PMID:2300054 - Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.

Nadin-Davis SA et al. Mol Cell Biol 1990 Feb;10(2):549-60

PMID:10395922 - Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe.

Kawamukai M Biochim Biophys Acta 1999 Jul 07;1446(1-2):93-101

PMID:9315645 - Multiple regulatory domains on the Byr2 protein kinase.

Tu H et al. Mol Cell Biol 1997 Oct;17(10):5876-87

PMID:7923372 - Cooperative interaction of S. pombe proteins required for mating and morphogenesis.

Chang EC et al. Cell 1994 Oct 07;79(1):131-41

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.

Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905

PMID:8443406 - Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

Neiman AM et al. Mol Biol Cell 1993 Jan;4(1):107-20

PMID:11683500 - Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.

Henkel J et al. Differentiation 2001 Jun;67(4-5):98-106

PMID:9135147 - Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.

Zaitsevskaya-Carter T et al. EMBO J 1997 Mar 17;16(6):1318-31

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs