protein coding gene - pdi1 (SPAC1F5.02) - ER protein disulfide isomerase

Gene summary

Standard name: pdi1
Systematic ID: SPAC1F5.02
Product: ER protein disulfide isomerase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q10057
ORFeome ID: 23/23H01
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 291979..293805 reverse strand

Annotation

Disease association

MONDO:0007204 - Cole-Carpenter syndrome 1

References:

PB_REF:0000006

GO biological process

GO:0034975 - protein folding in endoplasmic reticulum

References:

GO_REF:0000111

GO:0034976 - response to endoplasmic reticulum stress

References:

GO_REF:0000033

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

PMID:16823372

GO:0005788 - endoplasmic reticulum lumen

References:

GO_REF:0000024

GO molecular function

GO:0003756 - protein disulfide isomerase activity

References:

GO_REF:0000033

GO:0015035 - protein-disulfide reductase activity

References:

GO_REF:0000024

Modification

MOD:00689 - disulfide crosslinked residues

References:

PMID:36408920

MOD:00006 - N-glycosylated residue

References:

PMID:22633491

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

Protein features

PBO:0111760 - thioredoxin family

Protein sequence feature

SO:0000418 - signal_peptide

References:

PMID:36408920

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

PMID:23697806

Genotypes:

pdi1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

pdi1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF13848	Thioredoxin_6		PFAM
PF00085	Thioredoxin	Thioredoxin_domain	PFAM
cd02982	PDI_b'_family		CDD
cd02981	PDI_b_family		CDD
cd02995	PDI_a_PDI_a'_C		CDD
cd02961	PDI_a_family		CDD
PS00194	THIOREDOXIN_1	Thioredoxin_CS	PROSITE_PATTERNS
PS51352	THIOREDOXIN_2	Thioredoxin_domain	PROSITE_PROFILES
PR00421	THIOREDOXIN		PRINTS
G3DSA:3.40.30.10:FF:000027			FUNFAM
G3DSA:3.40.30.10:FF:000017			FUNFAM
SSF52833	Thioredoxin-like	Thioredoxin-like_sf	SUPERFAMILY
G3DSA:3.40.30.10	Glutaredoxin		GENE3D
PTHR18929	PROTEIN DISULFIDE ISOMERASE		PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolyte	disorder_prediction		MOBIDB-Negative-Polyelectrolyte
TIGR01130	ER_PDI_fam	Prot_disulphide_isomerase	NCBIFAM
TIGR01126	pdi_dom	PDI_thioredoxin-like_dom	NCBIFAM

Orthologs

PDIA2 (HGNC:14180) Homo sapiens
PDIA4 (HGNC:30167) Homo sapiens
PDIA3 (HGNC:4606) Homo sapiens
P4HB (HGNC:8548) Homo sapiens
pdi1 (SJAG_00288) Schizosaccharomyces japonicus
PDI1 (YCL043C) Saccharomyces cerevisiae
EUG1 (YDR518W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.: Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.: Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.: Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.: Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6