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protein coding gene - pdi1 (SPAC1F5.02) - ER protein disulfide isomerase

Gene summary

Standard name
pdi1
Systematic ID
SPAC1F5.02
Product
ER protein disulfide isomerase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10057
ORFeome ID
23/23H01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 291979..293805 reverse strand

Annotation

Disease association

MONDO:0007204 - Cole-Carpenter syndrome 1

References:

GO biological process

GO:0034975 - protein folding in endoplasmic reticulum

References:

GO:0034976 - response to endoplasmic reticulum stress

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005788 - endoplasmic reticulum lumen

References:

GO molecular function

GO:0003756 - protein disulfide isomerase activity

References:

GO:0015035 - protein-disulfide reductase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111760 - thioredoxin family

Protein sequence feature

SO:0000418 - signal_peptide

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00085ThioredoxinThioredoxin_domainPfam
PF13848Thioredoxin_6Pfam
cd02961PDI_a_familyCDD
cd02981PDI_b_familyCDD
cd02982PDI_b'_familyCDD
cd02995PDI_a_PDI_a'_CCDD
PS00194THIOREDOXIN_1Thioredoxin_CSPROSITE patterns
PS51352THIOREDOXIN_2Thioredoxin_domainPROSITE profiles
PR00421THIOREDOXINPRINTS
G3DSA:3.40.30.10:FF:000017CATH-FunFam
G3DSA:3.40.30.10:FF:000027CATH-FunFam
G3DSA:3.40.30.10Thioredoxin-like_sfCATH-Gene3D
SSF52833Thioredoxin-like_sfSUPERFAMILY
PTHR18929PANTHER
TIGR01126pdi_domPDI_thioredoxin-like_domNCBIFAM
TIGR01130ER_PDI_famProt_disulphide_isomeraseNCBIFAM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25963819 - Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.
Lucena R et al. J Cell Biol 2015 May 11;209(3):387-402
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493