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protein coding gene - cdc12 (SPAC1F5.04c) - cytokinetic formin Cdc12

Gene summary

Standard name
cdc12
Systematic ID
SPAC1F5.04c
Product
cytokinetic formin Cdc12
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10059
ORFeome ID
31/31B07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 283344..289200 forward strand

Annotation

Disease association

MONDO:0007424 - autosomal dominant nonsyndromic hearing loss 1

References:

MONDO:0014714 - progressive microcephaly-seizures-cortical blindness-developmental delay syndrome

References:

GO biological process

GO:0030041 - actin filament polymerization

References:

GO:0051016 - barbed-end actin filament capping

References:

GO:1903475 - mitotic actomyosin contractile ring assembly

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0005737 - cytoplasm

References:

GO:0031097 - medial cortex

References:

GO:0071341 - medial cortical node

References:

GO:0110085 - mitotic actomyosin contractile ring

References:

GO:0120104 - mitotic actomyosin contractile ring, proximal layer

References:

GO molecular function

GO:0051015 - actin filament binding

References:

GO:1990808 - F-bar domain binding

References:

GO:0005515 - protein binding

References:

GO:0031267 - small GTPase binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000742 - abnormal protein localization to actin cortical patch

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0007966 - abolished nuclear displacement from cell division site after abolished mitotic sister chromatid separation

References:

Genotypes:

FYPO:0003371 - abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm

References:

Genotypes:

FYPO:0006027 - actin cables present in increased numbers

References:

Genotypes:

FYPO:0006938 - actin cables present in increased numbers during cytokinesis

References:

Genotypes:

FYPO:0006939 - asymmetric actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0006940 - asymmetric protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0004470 - decreased protein localization to actomyosin contractile ring during mitotic anaphase

References:

Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0005022 - decreased rate of protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000729 - delayed onset of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0001919 - fragmented nucleus during vegetative growth

References:

Genotypes:

FYPO:0005870 - incomplete septum

References:

Genotypes:

FYPO:0006941 - increased duration of protein localization to actin cortical patch

References:

Genotypes:

FYPO:0006081 - increased protein localization to actin cortical patch

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

References:

Genotypes:

FYPO:0001493 - inviable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0002025 - inviable elongated multinucleate vegetative cell with abnormal septum morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0007664 - mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0000061 - multinucleate vegetative cell

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0007689 - normal cell growth polarization

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0002999 - normal protein localization to medial cortical node

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0007742 - premature actomyosin contractile ring assembly during mitotic interphase

References:

Genotypes:

FYPO:0007743 - premature septum assembly during mitotic interphase

References:

Genotypes:

FYPO:0002439 - short, thick, misoriented actin cables

References:

Genotypes:

FYPO:0002437 - thick actin cables

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002373 - abnormal actin cortical patch localization during mitosis

References:

Genotypes:

FYPO:0002374 - abnormal actin cortical patch morphology during mitosis

References:

Genotypes:

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0002872 - abnormal endoplasmic reticulum localization

References:

Genotypes:

FYPO:0002560 - abnormal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0000731 - abnormal protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0003158 - abolished actin cable assembly

References:

Genotypes:

FYPO:0003000 - abolished actin filament polymerization

References:

Genotypes:

FYPO:0002998 - abolished actomyosin contractile ring assembly, clumped medial cortical nodes

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0001880 - abolished protein localization to cell division site

References:

Genotypes:

FYPO:0006447 - abolished protein localization to cleavage furrow during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0000272 - abolished septum assembly

References:

Genotypes:

FYPO:0006938 - actin cables present in increased numbers during cytokinesis

References:

Genotypes:

FYPO:0004747 - actin cortical patches present in increased numbers at cell tip during early mitosis

References:

Genotypes:

FYPO:0003001 - actin filaments present in increased numbers

References:

Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0005853 - aggregated filamentous actin in cytoplasm

References:

Genotypes:

FYPO:0006939 - asymmetric actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002656 - decreased actin filament binding

References:

Genotypes:

FYPO:0007060 - decreased actin filament depolymerization involved in actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0007898 - decreased actomyosin contractile ring actin filament length

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0004737 - decreased F-actin level in actomyosin contractile ring during early mitosis

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002699 - decreased protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0005467 - decreased protein localization to actomyosin contractile ring during mitosis

References:

Genotypes:

FYPO:0004470 - decreased protein localization to actomyosin contractile ring during mitotic anaphase

References:

Genotypes:

FYPO:0002869 - decreased protein localization to cell division site

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0003339 - decreased rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0005022 - decreased rate of protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000729 - delayed onset of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0005870 - incomplete septum

References:

Genotypes:

FYPO:0006941 - increased duration of protein localization to actin cortical patch

References:

Genotypes:

FYPO:0006081 - increased protein localization to actin cortical patch

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002911 - inviable after spore germination, without cell division, with swollen elongated germ tube

References:

Genotypes:

FYPO:0003968 - inviable after spore germination, without cell division, with swollen elongated germ tube and bidirectional cell growth from spore body

References:

Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0001493 - inviable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0002025 - inviable elongated multinucleate vegetative cell with abnormal septum morphology

References:

Genotypes:

FYPO:0001006 - inviable elongated multinucleate vegetative cell with central constriction

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003210 - mislocalized, misoriented septum

References:

Genotypes:

FYPO:0007858 - mitotic DNA re-replication in absence of mitotic spindle

References:

Genotypes:

FYPO:0002424 - normal actin cortical patch localization during mitotic interphase

References:

Genotypes:

FYPO:0004740 - normal actomyosin contractile ring

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0003876 - normal cytokinesis checkpoint

References:

Genotypes:

FYPO:0005020 - normal duration of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0004741 - normal F-actin level in actomyosin contractile ring during anaphase B

References:

Genotypes:

FYPO:0001400 - normal interphase microtubules

References:

Genotypes:

FYPO:0005905 - normal onset of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0002558 - normal protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002999 - normal protein localization to medial cortical node

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0003126 - post-anaphase array absent from cell

References:

Genotypes:

FYPO:0001904 - premature actomyosin contractile ring disassembly

References:

Genotypes:

FYPO:0002437 - thick actin cables

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

FYPO:0007683 - wide actin fusion focus

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF06367Drf_FH3FH3_domPFAM
PF06371Drf_GBDGTPase-bdPFAM
PF02181FH2FH2_ForminPFAM
PS51232GBD_FH3GBD/FH3_domPROSITE_PROFILES
PS51444FH2FH2_ForminPROSITE_PROFILES
SM01140Drf_GBD_2GTPase-bdSMART
SM00498it6_sourceFH2_ForminSMART
SM01139Drf_FH3_2FH3_domSMART
G3DSA:1.25.10.10:FF:000997FUNFAM
G3DSA:1.20.58.2220:FF:000006FUNFAM
SSF101447Formin homology 2 domain (FH2 domain)SUPERFAMILY
SSF48371ARM repeatARM-type_foldSUPERFAMILY
G3DSA:1.25.10.10ARM-likeGENE3D
G3DSA:1.20.58.2220Formin, FH2 domainFH2_Formin_sfGENE3D
G3DSA:6.10.30.50GENE3D
PTHR47102PROTEIN BNI1Actin_filament_regulatorPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:12939254 - The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe.
Carnahan RH et al. J Cell Biol 2003 Sep 01;162(5):851-62
PMID:11448769 - Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression.
Trautmann S et al. Curr Biol 2001 Jun 26;11(12):931-40
PMID:18184749 - The actomyosin ring recruits early secretory compartments to the division site in fission yeast.
Vjestica A et al. Mol Biol Cell 2008 Mar;19(3):1125-38
PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.
Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57
PMID:27206859 - TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
Baker K et al. J Cell Sci 2016 Jul 01;129(13):2613-24
PMID:34613787 - Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis.
Malla M et al. Mol Biol Cell 2022 May 15;33(6):ar51
PMID:10469572 - Movement of a cytokinesis factor cdc12p to the site of cell division.
Chang F Curr Biol 1999 Jul 29;9(15):849-52
PMID:16864655 - Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.
Wu JQ et al. J Cell Biol 2006 Jul 31;174(3):391-402
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:16687577 - Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.
Wachtler V et al. Mol Biol Cell 2006 Jul;17(7):3254-66
PMID:24127216 - The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Coffman VC et al. J Cell Biol 2013 Oct 14;203(1):101-14
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:18272786 - Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.
Ge W et al. Mol Biol Cell 2008 Apr;19(4):1680-92
PMID:31217286 - Increasing ergosterol levels delays formin-dependent assembly of F-actin cables and disrupts division plane positioning in fission yeast.
Arbizzani F et al. J Cell Sci 2019 Jul 01;132(13)
PMID:38603491 - Molecular mechanism of actin filament elongation by formins.
Oosterheert W et al. Science 2024 Apr 12;384(6692):eadn9560
PMID:8978670 - Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.
Balasubramanian MK et al. EMBO J 1996 Dec 02;15(23):6426-37
PMID:20434336 - The cortical ER network limits the permissive zone for actomyosin ring assembly.
Zhang D et al. Curr Biol 2010 Jun 08;20(11):1029-34
PMID:22918943 - Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.
Saha S et al. Mol Biol Cell 2012 Oct;23(20):3982-92
PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.
Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26
PMID:9635188 - Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.
Eng K et al. Curr Biol 1998 May 21;8(11):611-21
PMID:20226666 - Regulation of cytokinesis by the formin cdc12p.
Yonetani A et al. Curr Biol 2010 Mar 23;20(6):561-6
PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.
Pardo M et al. Science 2003 Jun 06;300(5625):1569-74
PMID:26941334 - Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
Wei B et al. Mol Biol Cell 2016 Apr 15;27(8):1235-45
PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
PMID:19075108 - Assembly of normal actomyosin rings in the absence of Mid1p and cortical nodes in fission yeast.
Huang Y et al. J Cell Biol 2008 Dec 15;183(6):979-88
PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.
Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:21422229 - Assembly and architecture of precursor nodes during fission yeast cytokinesis.
Laporte D et al. J Cell Biol 2011 Mar 21;192(6):1005-21
PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.
Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56
PMID:18305104 - Regulation and targeting of the fission yeast formin cdc12p in cytokinesis.
Yonetani A et al. Mol Biol Cell 2008 May;19(5):2208-19
PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.
Wu JQ et al. Science 2005 Oct 14;310(5746):310-4
PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.
Nakano K et al. Genes Cells 2006 Aug;11(8):893-905
PMID:29343550 - Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
Willet AH et al. Mol Biol Cell 2018 Mar 15;29(6):713-721
PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23185032 - Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast.
Huang J et al. J Cell Biol 2012 Nov 26;199(5):831-47
PMID:23589458 - Insight into actin organization and function in cytokinesis from analysis of fission yeast mutants.
Subramanian D et al. Genetics 2013 Jun;194(2):435-46
PMID:25688133 - The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.
Willet AH et al. J Cell Biol 2015 Feb 16;208(4):391-9
PMID:26702831 - Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.
McDonald NA et al. Dev Cell 2015 Dec 21;35(6):725-36
PMID:30709916 - A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing.
Onwubiko UN et al. J Cell Sci 2019 Feb 28;132(5)
PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.
Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801
PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.
Gómez-Gil E et al. Elife 2020 Sep 11;9
PMID:35108037 - Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
Snider CE et al. Mol Biol Cell 2022 Apr 01;33(4):br4
PMID:36749320 - Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
Bhattacharjee R et al. Elife 2023 Feb 07;12
PMID:12214236 - Actin dynamics in the contractile ring during cytokinesis in fission yeast.
Pelham RJ et al. Nature 2002 Sep 05;419(6902):82-6
PMID:12796476 - The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.
Kovar DR et al. J Cell Biol 2003 Jun 09;161(5):875-87
PMID:30266808 - Dissection of two parallel pathways for formin-mediated actin filament elongation.
Sherer LA et al. J Biol Chem 2018 Nov 16;293(46):17917-17928
PMID:9105045 - cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.
Chang F et al. J Cell Biol 1997 Apr 07;137(1):169-82
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11854409 - The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe.
Wang H et al. Mol Biol Cell 2002 Feb;13(2):515-29
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:10769212 - Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe.
Motegi F et al. J Cell Sci 2000 May;113 ( Pt 10):1813-25
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:10087262 - Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.
Katayama S et al. J Cell Biol 1999 Mar 22;144(6):1173-86
PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.
Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75
PMID:24115772 - SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
Bohnert KA et al. Genes Dev 2013 Oct 01;27(19):2164-77
PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
Jourdain I et al. PLoS One 2013;8(1):e54142
PMID:35673994 - Actin assembly requirements of the formin Fus1 to build the fusion focus.
Billault-Chaumartin I et al. J Cell Sci 2022 Jul 01;135(13)
PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
PMID:10371213 - Identification of cold-sensitive mutations in the Schizosaccharomyces pombe actin locus.
McCollum D et al. FEBS Lett 1999 May 28;451(3):321-6
PMID:31495586 - Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.
Billault-Chaumartin I et al. Curr Biol 2019 Oct 07;29(19):3165-3176.e6
PMID:33506191 - Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast.
Yukawa M et al. iScience 2021 Jan 22;24(1):102031
PMID:22056467 - Formins filter modified actin subunits during processive elongation.
Chen Q et al. J Struct Biol 2012 Jan;177(1):32-9
PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24954052 - Formins determine the functional properties of actin filaments in yeast.
Johnson M et al. Curr Biol 2014 Jul 07;24(13):1525-30
PMID:31116668 - Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis.
Morris Z et al. Mol Biol Cell 2019 Jul 15;30(15):1791-1804
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:18256290 - Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
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