PomBase home

protein coding gene - lsh1 (SPAC1F5.06) - ER heat shock protein Lsh1

Gene summary

Standard name
lsh1
Systematic ID
SPAC1F5.06
Product
ER heat shock protein Lsh1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10061
ORFeome ID
29/29C12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 276657..281232 reverse strand

Annotation

Disease association

MONDO:0009305 - granulocytopenia with immunoglobulin abnormality

References:

GO biological process

GO:0034975 - protein folding in endoplasmic reticulum

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0034663 - endoplasmic reticulum chaperone complex

References:

GO:0005788 - endoplasmic reticulum lumen

References:

GO molecular function

GO:0000774 - adenyl-nucleotide exchange factor activity

References:

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

Miscellaneous functional group

PBO:0000255 - chaperone

Modification

MOD:00006 - N-glycosylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000312 - inviable after spore germination with normal, septated germ tube morphology

References:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00012HSP70Hsp_70_famPFAM
cd10230ASKHA_NBD_HSP70_HYOU1CDD
PS01036HSP70_3Heat_shock_70_CSPROSITE_PATTERNS
PS00329HSP70_2Heat_shock_70_CSPROSITE_PATTERNS
PR00301HEATSHOCK70PRINTS
G3DSA:3.30.30.30:FF:000004FUNFAM
G3DSA:1.20.1270.10:FF:000098FUNFAM
G3DSA:3.90.640.10:FF:000003FUNFAM
SSF100934Heat shock protein 70kD (HSP70), C-terminal subdomainHSP70_C_sfSUPERFAMILY
SSF53067Actin-like ATPase domainATPase_NBDSUPERFAMILY
G3DSA:3.90.640.10Actin; Chain A, domain 4GENE3D
G3DSA:3.30.420.40GENE3D
G3DSA:3.30.30.30GENE3D
G3DSA:1.20.1270.10HSP70_C_sfGENE3D
PTHR45639HSC70CB, ISOFORM G-RELATEDHsp_70_famPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000002 - Comments
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7