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protein coding gene - fal1 (SPAC1F5.10) - exon junction complex subunit, ATP-dependent RNA helicase Fal1 (conflicting process, human yeast)

Gene summary

Standard name
fal1
Systematic ID
SPAC1F5.10
Product
exon junction complex subunit, ATP-dependent RNA helicase Fal1 (conflicting process, human yeast)
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10055
ORFeome ID
22/22F09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 270893..272342 reverse strand

Annotation

Disease association

MONDO:0009998 - Richieri Costa-Pereira syndrome

References:

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO:0071030 - nuclear mRNA surveillance of spliceosomal pre-mRNA splicing

References:

GO:0006364 - rRNA processing

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GO cellular component

GO:0071013 - catalytic step 2 spliceosome

References:

GO:0000785 - chromatin

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GO:0005829 - cytosol

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GO:0035145 - exon-exon junction complex

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GO:0030874 - nucleolar chromatin

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GO:0005634 - nucleus

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0003729 - mRNA binding

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GO:0003724 - RNA helicase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0008320 - abnormal cell morphology during sulphur deprivation

References:

Genotypes:

Protein features

PBO:0111747 - DEAD/DEAH box helicase

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0008147 - decreased mRNA splicing, meiotic genes

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Genotypes:

FYPO:0004937 - decreased RNA level during meiosis I

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0007086 - elongated vegetative cell during sulfur starvation

References:

Genotypes:

FYPO:0002960 - increased level of DSR-containing meiotic gene mRNA during vegetative growth

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Genotypes:

FYPO:0008427 - increased protein level during cellular response to sulfur starvation

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0008319 - normal macroautophagy during sulfur starvation

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00271Helicase_CHelicase_C-likePFAM
PF00270DEADDEAD/DEAH_box_helicase_domPFAM
cd18045DEADc_EIF4AIII_DDX48CDD
cd18787SF2_C_DEADCDD
PS00039DEAD_ATP_HELICASERNA-helicase_DEAD-box_CSPROSITE_PATTERNS
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE_PROFILES
PS51194HELICASE_CTERHelicase_C-likePROSITE_PROFILES
PS51195Q_MOTIFRNA_helicase_DEAD_Q_motifPROSITE_PROFILES
SM00490helicmild6Helicase_C-likeSMART
SM00487ultradead3Helicase_ATP-bdSMART
G3DSA:3.40.50.300:FF:000498FUNFAM
G3DSA:3.40.50.300:FF:000031FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR47958ATP-DEPENDENT RNA HELICASE DBP3PANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.
Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680
PMID:27365210 - The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis.
Marayati BF et al. RNA 2016 Sep;22(9):1349-59
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
GO_REF:0000002 - Comments
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.
Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64