protein coding gene - tra2 (SPAC1F5.11c) - NuA4 complex phosphatidylinositol pseudokinase complex subunit Tra2

Gene summary

Standard name

tra2

Systematic ID

SPAC1F5.11c

Product

NuA4 complex phosphatidylinositol pseudokinase complex subunit Tra2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10064

ORFeome ID

34/34D08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 259611..271053 forward strand

Annotation

Protein features

Orthologs

• TRRAP (HGNC:12347) Homo sapiens
• tra2 (SJAG_05282) Schizosaccharomyces japonicus
• TRA1 (YHR099W) Saccharomyces cerevisiae

References / Literature

PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70

PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238

PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.

Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.

Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.

Inoue H et al. Genes Cells 2017 Jan;22(1):59-70

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:19040720 - Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Shevchenko A et al. Genome Biol 2008;9(11):R167

PMID:18076567 - Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

Kanoh J et al. Genes Cells 2007 Dec;12(12):1301-4

PMID:19915592 - An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.

Kim HS et al. Nat Struct Mol Biol 2009 Dec;16(12):1286-93

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405