protein coding gene - cdc22 (SPAC1F7.05) - ribonucleoside reductase large subunit Cdc22

Gene summary

Standard name

cdc22

Systematic ID

SPAC1F7.05

Product

ribonucleoside reductase large subunit Cdc22

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36602

ORFeome ID

47/47B09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4226970..4229989 forward strand

Annotation

Protein features

Orthologs

• RRM1 (HGNC:10451) Homo sapiens
• cdc22 (SJAG_04665) Schizosaccharomyces japonicus
• RNR1 (YER070W) Saccharomyces cerevisiae
• RNR3 (YIL066C) Saccharomyces cerevisiae

References / Literature

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

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PMID:9950674 - Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.

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PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

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PMID:28903048 - Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

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PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

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PMID:12455694 - mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.

Williams DR et al. Eukaryot Cell 2002 Oct;1(5):758-73

PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.

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PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

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PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.

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PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

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PMID:9268024 - Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function.

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PMID:24006488 - The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

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PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

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PMID:35157728 - TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes.

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PMID:8842148 - Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast.

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PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

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PMID:16317005 - The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.

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PMID:7739540 - The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.

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PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

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PMID:19750219 - The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.

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PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

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PMID:8479429 - The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase.

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PMID:18030666 - Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast.

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PMID:20231270 - Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

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PMID:7796804 - A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

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PMID:18753627 - Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

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PMID:25492408 - Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.

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PMID:8838655 - Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins.

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PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

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PMID:10683155 - A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.

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PMID:9154809 - A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.

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PMID:31719112 - Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.

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PMID:9679144 - Regulation of cell polarity by microtubules in fission yeast.

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PMID:8657126 - Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.

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PMID:2406029 - Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.

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PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.

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PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

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PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

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PMID:31260531 - Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.

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PMID:23986475 - Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.

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PMID:11313455 - Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures.

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PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.

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PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

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PMID:1734281 - Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+.

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PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

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PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

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PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

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PMID:6273154 - The cdc 22 mutation by Schizosaccharomyces pombe is a temperature-sensitive defect in nucleoside diphosphokinase.

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PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

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PMID:8313888 - cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

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PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

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PMID:11359920 - Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

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PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

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PMID:24652833 - Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

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PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

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PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

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PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

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PMID:19933844 - Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.

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PMID:7768995 - The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis.

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PMID:9572736 - Replication checkpoint enforced by kinases Cds1 and Chk1.

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PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

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PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

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PMID:10588642 - Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.

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PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

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PMID:9153313 - Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.

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GO_REF:0000033 - Annotation inferences using phylogenetic trees