protein coding gene - fio1 (SPAC1F7.08) - plasma membrane iron transport multicopper oxidase Fio1
Gene summary
- Standard name
- fio1
- Systematic ID
- SPAC1F7.08
- Product
- plasma membrane iron transport multicopper oxidase Fio1
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- UniProt ID
- Q09920
- ORFeome ID
- 46/46A07
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome I: 4235072..4237874 forward strand
Annotation
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF00394 | Cu-oxidase | Cu-oxidase_2nd | PFAM |
| PF07731 | Cu-oxidase_2 | Cu-oxidase_C | PFAM |
| PF07732 | Cu-oxidase_3 | Cu-oxidase-like_N | PFAM |
| cd13877 | CuRO_2_Fet3p_like | CuRO_2_Fet3-like | CDD |
| cd13899 | CuRO_3_Fet3p | | CDD |
| PS00079 | MULTICOPPER_OXIDASE1 | Cu_oxidase_CS | PROSITE_PATTERNS |
| PS00080 | MULTICOPPER_OXIDASE2 | Cu_oxidase_Cu_BS | PROSITE_PATTERNS |
| SSF49503 | Cupredoxins | Cupredoxin | SUPERFAMILY |
| G3DSA:2.60.40.420 | | Cupredoxin | GENE3D |
| PTHR11709 | MULTI-COPPER OXIDASE | Cu-oxidase_fam | PANTHER |
Orthologs
- fio1 (SJAG_04677) Schizosaccharomyces japonicus
- GMC1 (YDR506C) Saccharomyces cerevisiae
- FET5 (YFL041W) Saccharomyces cerevisiae
- FET3 (YMR058W) Saccharomyces cerevisiae
References / Literature
- PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
- Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
- PMID:10593913 - A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.
- Labbé S et al. J Biol Chem 1999 Dec 17;274(51):36252-60
- PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
- Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
- PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
- Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
- PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
- Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
- PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
- Guydosh NR et al. Elife 2017 Sep 25;6
- PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
- Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
- PMID:16963626 - A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.
- Mercier A et al. Eukaryot Cell 2006 Nov;5(11):1866-81
- PMID:11956219 - Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.
- Pelletier B et al. J Biol Chem 2002 Jun 21;277(25):22950-8
- PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
- Rustici G et al. Genome Biol 2007;8(5):R73
- PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.
- Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24
- PMID:19915076 - abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe.
- Pouliot B et al. Eukaryot Cell 2010 Jan;9(1):59-73
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
- Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
- PMID:12888492 - Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system.
- Pelletier B et al. Nucleic Acids Res 2003 Aug 01;31(15):4332-44
- PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
- Su Y et al. FEBS J 2017 Jan;284(2):324-337
- PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
- Schwer B et al. mBio 2024 Jun 20;:e0125224
- PMID:18223116 - Key function for the CCAAT-binding factor Php4 to regulate gene expression in response to iron deficiency in fission yeast.
- Mercier A et al. Eukaryot Cell 2008 Mar;7(3):493-508
- PMID:15866870 - Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.
- Pelletier B et al. J Biol Chem 2005 Jul 01;280(26):25146-61
- PMID:25733668 - Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.
- Mourer T et al. J Biol Chem 2015 Apr 17;290(16):10176-90
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:25806539 - A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.
- Encinar del Dedo J et al. PLoS Genet 2015 Mar;11(3):e1005106
- GO_REF:0000002 - Comments
-
- PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
- Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
- PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
- Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
- PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
- Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
- PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.
- Bednor L et al. mBio 2023 Dec 22;:e0306223
- PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
- Rallis C et al. Sci Rep 2017 Mar 10;7:44257
- PMID:28882432 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe.
- Higuchi Y et al. J Biosci Bioeng 2018 Jan;125(1):92-96
- PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
- Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
- PMID:24897379 - Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.
- Jacques JF et al. PLoS One 2014;9(6):e98959
- PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
- Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
- PMID:35079912 - Identification and analysis of iron transporters from the fission yeast Schizosaccharomyces pombe.
- Ahmad F et al. Arch Microbiol 2022 Jan 26;204(2):152
- PMID:21531205 - Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.
- Kim KD et al. Biochem Biophys Res Commun 2011 May 20;408(4):609-14
- PMID:29878109 - Disruption of ppr3, ppr4, ppr6 or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe.
- Su Y et al. FEMS Microbiol Lett 2018 Aug 01;365(16)
- PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
- Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
- Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
- PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
- UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
- PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.
- Garg A et al. RNA 2021 Feb 12;27(5):560-70
- PMID:8995275 - An oxidase-permease-based iron transport system in Schizosaccharomyces pombe and its expression in Saccharomyces cerevisiae.
- Askwith C et al. J Biol Chem 1997 Jan 03;272(1):401-5
- PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.
- Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51
- PMID:30393157 - Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
- Shang J et al. Fungal Genet Biol 2019 Jan;122:11-20
- PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.
- Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:35657410 - Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.
- Liu Z et al. Arch Microbiol 2022 Jun 03;204(7):360
- PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
- Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
- GO_REF:0000033 - Annotation inferences using phylogenetic trees
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- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
- Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
- PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
- Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
