protein coding gene - SPAC1F7.11c - DNA-binding transcription factor, zf-fungal binuclear cluster type

Gene summary

Systematic ID: SPAC1F7.11c
Product: DNA-binding transcription factor, zf-fungal binuclear cluster type
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q09922
ORFeome ID: 29/29A06
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 4244723..4247816 reverse strand

Annotation

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO_REF:0000050

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

GO_REF:0000050

GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

References:

GO_REF:0000002

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO_REF:0000050

GO:0008270 - zinc ion binding

References:

GO_REF:0000002

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

Protein features

PBO:0111744 - zf-fungal Zn(2)-Cys(6) binuclear cluster domain

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

PMID:29259000

Genotypes:

SPAC1F7.11cdelta/SPAC1F7.11cdelta

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0004167 - increased cell population growth on glycerol carbon source

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0004557 - increased vegetative cell population growth

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0006518 - loss of viability in G0

References:

PMID:33260998

Genotypes:

SPAC1F7.11cdelta

FYPO:0000245 - loss of viability in stationary phase

References:

PMID:35820914

Genotypes:

SPAC1F7.11cdelta

FYPO:0007553 - normal G1 to G0 transition

References:

PMID:33260998

Genotypes:

SPAC1F7.11cdelta

FYPO:0009036 - resistance to benzamidine

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0000763 - resistance to cadmium

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0001450 - resistance to cold

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009038 - resistance to egtazic acid

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0001453 - resistance to ethanol

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0001103 - resistance to hydrogen peroxide

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0002578 - resistance to hydroxyurea

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0001583 - resistance to lithium

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0000725 - resistance to methyl methanesulfonate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

PMID:37787768

Genotypes:

SPAC1F7.11cdelta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

SPAC1F7.11cdelta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPAC1F7.11cdelta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000110 - orthologs cannot be distinguished

Protein features

ID	Name	InterPro name	DB name
PF04082	Fungal_trans	XnlR_reg_dom	PFAM
cd00067	GAL4	Zn2Cys6_DnaBD	CDD
cd12148	fungal_TF_MHR		CDD
PS00463	ZN2_CY6_FUNGAL_1	Zn2Cys6_DnaBD	PROSITE_PATTERNS
PS50048	ZN2_CY6_FUNGAL_2	Zn2Cys6_DnaBD	PROSITE_PROFILES
SM00066	gal4_2	Zn2Cys6_DnaBD	SMART
SM00906	Fungal_trans_2	XnlR_reg_dom	SMART
SSF57701	Zn2/Cys6 DNA-binding domain	Zn2-C6_fun-type_DNA-bd_sf	SUPERFAMILY
G3DSA:4.10.240.10		Zn2-C6_fun-type_DNA-bd_sf	GENE3D
PTHR31001	UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN		PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

Orthologs

SJAG_00037 Schizosaccharomyces japonicus

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.: Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.: Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.: Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.: Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)