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protein coding gene - shu1 (SPAC1F8.02c) - cell-surface heme acquisition protein Shu1

Gene summary

Standard name
shu1
Systematic ID
SPAC1F8.02c
Product
cell-surface heme acquisition protein Shu1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q92340
ORFeome ID
42/42H09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 85566..86278 reverse strand

Annotation

GO biological process

GO:0010106 - cellular response to iron ion starvation

References:

GO:0140420 - heme import into cell

References:

GO:0015886 - heme transport

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GO:0016192 - vesicle-mediated transport

References:

GO:0098711 - iron ion import across plasma membrane

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GO cellular component

GO:0009897 - external side of plasma membrane

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GO:0000324 - fungal-type vacuole

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GO:0005886 - plasma membrane

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GO:0005774 - vacuolar membrane

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GO molecular function

GO:0020037 - heme binding

References:

GO:0140488 - heme receptor activity

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Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

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Multi-locus phenotype

FYPO:0007397 - abolished heme import

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Genotypes:

FYPO:0007396 - decreased heme import

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000051 - abnormal meiosis

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Genotypes:

FYPO:0004250 - abolished protein localization to vacuolar membrane

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Genotypes:

FYPO:0004698 - decreased heme binding

References:

Genotypes:

FYPO:0001852 - decreased transcription during iron starvation

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Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0003335 - increased galactose-specific flocculation

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Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Protein features

IDNameInterPro nameDB name
Signal PeptideDeepTMHMM-Signal-Peptide

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:25733668 - Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.
Mourer T et al. J Biol Chem 2015 Apr 17;290(16):10176-90
PMID:29549126 - The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombe .
Normant V et al. J Biol Chem 2018 Apr 27;293(17):6349-6362
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:30393157 - Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
Shang J et al. Fungal Genet Biol 2019 Jan;122:11-20
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Rustici G et al. Genome Biol 2007;8(5):R73
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.
Garg A et al. RNA 2021 Feb 12;27(5):560-70
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:35657410 - Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.
Liu Z et al. Arch Microbiol 2022 Jun 03;204(7):360
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29878109 - Disruption of ppr3, ppr4, ppr6 or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe.
Su Y et al. FEMS Microbiol Lett 2018 Aug 01;365(16)
PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837
PMID:28193844 - Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3.
Mourer T et al. J Biol Chem 2017 Mar 24;292(12):4898-4912
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;