protein coding gene - fus1 (SPAC20G4.02c) - formin Fus1

Gene summary

Standard name

fus1

Systematic ID

SPAC20G4.02c

Product

formin Fus1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10719

ORFeome ID

30/30F08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4813111..4817786 reverse strand

Annotation

Protein features

Orthologs

• DIAPH1 (HGNC:2876) Homo sapiens
• fus1 (SJAG_01943) Schizosaccharomyces japonicus
• BNR1 (YIL159W) Saccharomyces cerevisiae

References / Literature

PMID:41335110 - High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation.

Thomas V et al. J Cell Biol 2026 Feb 02;225(2)

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

GO_REF:0000051 - S. pombe keyword mapping

PMID:31495586 - Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.

Billault-Chaumartin I et al. Curr Biol 2019 Oct 07;29(19):3165-3176.e6

PMID:17032641 - Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Mata J et al. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15517-22

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:34382996 - Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion.

Muriel O et al. J Cell Biol 2021 Oct 04;220(10)

PMID:24514900 - Membrane organization and cell fusion during mating in fission yeast requires multipass membrane protein Prm1.

Curto MÁ et al. Genetics 2014 Apr;196(4):1059-76

PMID:36202103 - Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion.

Billault-Chaumartin I et al. Curr Biol 2022 Nov 07;32(21):4752-4761.e10

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:7791776 - Characterization of fus1 of Schizosaccharomyces pombe: a developmentally controlled function needed for conjugation.

Petersen J et al. Mol Cell Biol 1995 Jul;15(7):3697-707

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9606213 - FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation.

Petersen J et al. J Cell Biol 1998 Jun 01;141(5):1217-28

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.

Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.

Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:29134248 - The ancient claudin Dni2 facilitates yeast cell fusion by compartmentalizing Dni1 into a membrane subdomain.

Curto MÁ et al. Cell Mol Life Sci 2018 May;75(9):1687-1706

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:4472733 - Premeiotic DNA synthesis in fission yeast.

Egel R et al. Exp Cell Res 1974 Sep;88(1):127-34

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:9742398 - Conjugation in S. pombe: identification of a microtubule-organising centre, a requirement for microtubules and a role for Mad2.

Petersen J et al. Curr Biol 1998 Aug 27;8(17):963-6

PMID:21148300 - Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.

Bendezú FO et al. Mol Biol Cell 2011 Jan 01;22(1):44-53

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

GO_REF:0000002 - Comments

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:16598689 - The Schizosaccharomyces pombe cfr1+ gene participates in mating through a new pathway that is independent of fus1+.

Cartagena-Lirola H et al. Yeast 2006 Apr 15;23(5):375-88

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:30089908 - Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.

Vještica A et al. Nature 2018 Aug;560(7718):397-400

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:11952834 - Tropomyosin is required for the cell fusion process during conjugation in fission yeast.

Kurahashi H et al. Genes Cells 2002 Apr;7(4):375-84

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19627505 - The tetraspan protein Dni1p is required for correct membrane organization and cell wall remodelling during mating in Schizosaccharomyces pombe.

Clemente-Ramos JA et al. Mol Microbiol 2009 Aug;73(4):695-709

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:35673994 - Actin assembly requirements of the formin Fus1 to build the fusion focus.

Billault-Chaumartin I et al. J Cell Sci 2022 Jul 01;135(13)