protein coding gene - adf1 (SPAC20G4.06c) - actin depolymerizing factor, cofilin

Gene summary

Standard name

adf1

Systematic ID

SPAC20G4.06c

Product

actin depolymerizing factor, cofilin

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cof1

UniProt ID

P78929

ORFeome ID

07/07B10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4825257..4826126 reverse strand

Annotation

Protein features

Orthologs

• DSTN (HGNC:15750) Homo sapiens
• CFL1 (HGNC:1874) Homo sapiens
• CFL2 (HGNC:1875) Homo sapiens
• adf1 (SJAG_03025) Schizosaccharomyces japonicus
• COF1 (YLL050C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000044 - Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.

PMID:25451933 - Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.

Chen Q et al. J Biol Chem 2015 Jan 23;290(4):2289-300

PMID:20042603 - Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.

Mehta S et al. J Biol Chem 2010 Feb 26;285(9):6835-47

PMID:21148484 - Purification of actin from fission yeast Schizosaccharomyces pombe and characterization of functional differences from muscle actin.

Ti SC et al. J Biol Chem 2011 Feb 18;286(7):5784-92

PMID:25688133 - The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.

Willet AH et al. J Cell Biol 2015 Feb 16;208(4):391-9

PMID:34613787 - Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis.

Malla M et al. Mol Biol Cell 2022 May 15;33(6):ar51

PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.

Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:31927482 - Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

Antoine M et al. iScience 2020 Jan 24;23(1):100809

PMID:28282023 - Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.

Christensen JR et al. Elife 2017 Mar 10;6

PMID:19713940 - Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.

Takaine M et al. EMBO J 2009 Oct 21;28(20):3117-31

PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.

Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45

PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.

Nakano K et al. Genes Cells 2006 Aug;11(8):893-905

PMID:17018289 - Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.

Andrianantoandro E et al. Mol Cell 2006 Oct 06;24(1):13-23

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24954052 - Formins determine the functional properties of actin filaments in yeast.

Johnson M et al. Curr Biol 2014 Jul 07;24(13):1525-30

PMID:22024167 - Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.

Chen Q et al. J Cell Biol 2011 Oct 31;195(3):485-98

PMID:21642440 - Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.

Skau CT et al. J Biol Chem 2011 Jul 29;286(30):26964-77

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.

Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801

PMID:21723825 - Cofilin-linked changes in actin filament flexibility promote severing.

McCullough BR et al. Biophys J 2011 Jul 06;101(1):151-9

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:19362000 - Cofilin dissociates Arp2/3 complex and branches from actin filaments.

Chan C et al. Curr Biol 2009 Apr 14;19(7):537-45

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:20705466 - Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.

Skau CT et al. Curr Biol 2010 Aug 24;20(16):1415-22

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26542710 - Identification and characterization of Csh3 as an SH3 protein that interacts with fission yeast Cap1.

Yamamoto T et al. FEMS Yeast Res 2015 Dec;15(8)

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

PMID:30201262 - Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.

Ueda EI et al. Biochem Biophys Res Commun 2018 Nov 25;506(2):330-338

PMID:20517925 - GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton.

Nakano K et al. Cytoskeleton (Hoboken) 2010 Jun;67(6):373-82

PMID:23727096 - Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches.

Chen Q et al. Curr Biol 2013 Jul 08;23(13):1154-62

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83