PomBase home

protein coding gene - erg2 (SPAC20G8.07c) - C-8 sterol isomerase Erg2

Gene summary

Standard name
erg2
Systematic ID
SPAC20G8.07c
Product
C-8 sterol isomerase Erg2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87113
ORFeome ID
34/34D12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1410106..1411226 reverse strand

Annotation

Disease association

MONDO:0013715 - amyotrophic lateral sclerosis type 16

References:

MONDO:0011585 - autosomal recessive distal spinal muscular atrophy 2

References:

GO biological process

GO:0006696 - ergosterol biosynthetic process

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO molecular function

GO:0000247 - C-8 sterol isomerase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0000418 - signal_peptide

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005156 - abnormal ascus morphology

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000421 - abolished endocytosis during vegetative growth

References:

Genotypes:

FYPO:0010046 - abolished giant endoplasmic reticulum sheet formation during cellular response to saturated fatty acid

References:

Genotypes:

FYPO:0002128 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0004446 - decreased endocytosis during meiotic cell cycle

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0004448 - mislocalized protein during meiotic cell cycle

References:

Genotypes:

FYPO:0000426 - normal endocytosis

References:

Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

References:

Genotypes:

FYPO:0002717 - normal vacuole fusion during cellular hypotonic response

References:

Genotypes:

FYPO:0000070 - resistance to amphotericin B

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000076 - resistance to nystatin

References:

Genotypes:

FYPO:0010040 - resistance to pentadecanoic acid

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000113 - sensitive to staurosporine

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04622ERG2_Sigma1RERG2_sigma1_rcpt-likePfam
PTHR10868ERG2_sigma1_rcpt-likePANTHER
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:21832151 - Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.
Kashiwazaki J et al. Mol Biol Cell 2011 Oct;22(19):3658-70
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40424131 - Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast.
Hoshikawa Y et al. Proc Natl Acad Sci U S A 2025 Jun 03;122(22):e2422126122
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:18310029 - Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe.
Iwaki T et al. Microbiology (Reading) 2008 Mar;154(Pt 3):830-841
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12