protein coding gene - rad57 (SPAC20H4.07) - DNA recombination mediator, RecA family ATPase Rad57/Rhp57

Gene summary

Standard name

rad57

Systematic ID

SPAC20H4.07

Product

DNA recombination mediator, RecA family ATPase Rad57/Rhp57

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rhp57, SPAC145.01

UniProt ID

Q9UUL2

ORFeome ID

50/50D04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2123030..2124506 forward strand

Annotation

Protein features

Orthologs

• XRCC3 (HGNC:12830) Homo sapiens
• rad57 (SJAG_00757) Schizosaccharomyces japonicus
• RAD57 (YDR004W) Saccharomyces cerevisiae

References / Literature

PMID:24875629 - Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Ding L et al. G3 (Bethesda) 2014 May 28;4(8):1373-84

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:18231579 - The CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast.

Gerber HB et al. PLoS One 2008 Jan 30;3(1):e1492

PMID:23828040 - Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.

Dziadkowiec D et al. Nucleic Acids Res 2013 Sep;41(17):8196-209

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:11560889 - Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.

Tsutsui Y et al. Genetics 2001 Sep;159(1):91-105

GO_REF:0000051 - S. pombe keyword mapping

PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.

Roseaulin L et al. EMBO J 2008 May 07;27(9):1378-87

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:20655467 - Crossover invariance determined by partner choice for meiotic DNA break repair.

Hyppa RW et al. Cell 2010 Jul 23;142(2):243-55

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

GO_REF:0000002 - Comments

PMID:40083061 - Heterochromatin Protein Swi6 Suppresses Aberrant Gene Conversion at mat Loci by Adjusting the Balance Between the Two Pathways of Swi2 and Rad57.

Fujioka T et al. Genes Cells 2025 Mar;30(2):e70012

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:32204793 - Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex.

Argunhan B et al. Elife 2020 Mar 24;9

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:23297345 - Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.

Nanbu T et al. Mol Cell Biol 2013 Mar;33(6):1175-87

PMID:14663140 - Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

Akamatsu Y et al. Proc Natl Acad Sci U S A 2003 Dec 23;100(26):15770-5

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:17660542 - Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.

Dovey CL et al. Genetics 2007 Sep;177(1):47-61

PMID:22737087 - The CCR4-NOT complex is implicated in the viability of aneuploid yeasts.

Tange Y et al. PLoS Genet 2012;8(6):e1002776

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:16135799 - Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.

Morishita T et al. Mol Cell Biol 2005 Sep;25(18):8074-83

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:19185548 - The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

Dziadkowiec D et al. DNA Repair (Amst) 2009 May 01;8(5):627-36

PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24

PMID:21183410 - Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R et al. DNA Repair (Amst) 2011 Mar 07;10(3):283-95

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51

PMID:17304215 - Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.

Akamatsu Y et al. EMBO J 2007 Mar 07;26(5):1352-62

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:16354704 - Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

Miyabe I et al. Mol Cell Biol 2006 Jan;26(1):343-53

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:27304859 - Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S et al. PLoS Genet 2016 Jun;12(6):e1006102

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:14668362 - Five RecA-like proteins of Schizosaccharomyces pombe are involved in meiotic recombination.

Grishchuk AL et al. Genetics 2003 Nov;165(3):1031-43

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PMID:10747044 - A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene.

Tsutsui Y et al. Genetics 2000 Apr;154(4):1451-61

PMID:37330173 - Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.

Liang P et al. J Biol Chem 2023 Aug;299(8):104929

PMID:14993467 - The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast.

Doe CL et al. Nucleic Acids Res 2004;32(4):1480-91

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:15972456 - Brc1-mediated DNA repair and damage tolerance.

Sheedy DM et al. Genetics 2005 Oct;171(2):457-68

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:15336631 - Identification and characterization of the rlp1+, the novel Rad51 paralog in the fission yeast Schizosaccharomyces pombe.

Khasanov FK et al. DNA Repair (Amst) 2004 Oct 05;3(10):1363-74

PMID:12944481 - Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.

Ueno M et al. Mol Cell Biol 2003 Sep;23(18):6553-63

PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.

Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:19023408 - Indistinguishable landscapes of meiotic DNA breaks in rad50+ and rad50S strains of fission yeast revealed by a novel rad50+ recombination intermediate.

Hyppa RW et al. PLoS Genet 2008 Nov;4(11):e1000267

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25165823 - Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Tsutsui Y et al. PLoS Genet 2014 Aug;10(8):e1004542

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71