protein coding gene - tlh1 (SPAC212.11) - RecQ type DNA helicase, partial, C-terminal truncated compared to other tlh genes

Gene summary

Standard name

tlh1

Systematic ID

SPAC212.11

Product

RecQ type DNA helicase, partial, C-terminal truncated compared to other tlh genes

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P0CT33

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1..5662 reverse strand

Annotation

Protein features

Orthologs

• SJAG_05105 Schizosaccharomyces japonicus
• SJAG_05173 Schizosaccharomyces japonicus
• SJAG_06597 Schizosaccharomyces japonicus
• SJAG_06642 Schizosaccharomyces japonicus

References / Literature

PMID:27183912 - Translin and Trax differentially regulate telomere-associated transcript homeostasis.

Gomez-Escobar N et al. Oncotarget 2016 Jun 07;7(23):33809-20

PMID:22081013 - The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.

Schalch T et al. Nat Struct Mol Biol 2011 Nov 13;18(12):1351-7

PMID:27538348 - Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast.

Yu Y et al. Sci Rep 2016 Aug 19;6:31752

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29160296 - Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.

Xue J et al. Cell Res 2017 Dec;27(12):1503-1520

PMID:38415071 - The Cdc14 phosphatase, Clp1, does not affect genome expression.

Lopez Maury L et al. MicroPubl Biol 2024;2024

PMID:23771057 - Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

Alper BJ et al. EMBO J 2013 Aug 28;32(17):2321-35

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:32295063 - The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe .

Marayati BF et al. Cells 2020 Apr 13;9(4)

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:23133674 - Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.

Fujita I et al. PLoS One 2012;7(11):e49151

PMID:34524082 - SUV39 SET domains mediate crosstalk of heterochromatic histone marks.

Stirpe A et al. Elife 2021 Sep 15;10

PMID:26744419 - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.

Barrales RR et al. Genes Dev 2016 Jan 15;30(2):133-48

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101

PMID:29632066 - TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Cohen A et al. J Biol Chem 2018 May 25;293(21):8138-8150

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:15591066 - Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.

Mandell JG et al. J Biol Chem 2005 Feb 18;280(7):5249-57

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:26582768 - Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.

Gal C et al. EMBO Rep 2016 Jan;17(1):79-93

PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.

Bühler M et al. Cell 2007 May 18;129(4):707-21

PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24

PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.

Seo HD et al. Curr Genet 2018 Jun;64(3):741-752

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:32499408 - The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast.

Sun L et al. J Cell Sci 2020 Jul 07;133(13)

PMID:40520116 - Histone deacetylation as a landmark for Sgo2 relocation from centromeres to subtelomeres during interphase.

Osaki M et al. iScience 2025 Jun 20;28(6):112717

PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.

Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837

GO_REF:0000002 - Comments

PMID:26438724 - H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.

Stunnenberg R et al. EMBO J 2015 Nov 12;34(22):2789-803

PMID:29866182 - RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.

Okazaki K et al. Epigenetics Chromatin 2018 Jun 04;11(1):26

GO_REF:0000033 - Annotation inferences using phylogenetic trees