protein coding gene - pcr1 (SPAC21E11.03c) - DNA-binding pioneer transcription factor Pcr1

Gene summary

Standard name

pcr1

Systematic ID

SPAC21E11.03c

Product

DNA-binding pioneer transcription factor Pcr1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

mts2

UniProt ID

Q09926

ORFeome ID

05/05A11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4252142..4253600 reverse strand

Annotation

Protein features

Orthologs

• pcr1 (SJAG_02311) Schizosaccharomyces japonicus
• SKO1 (YNL167C) Saccharomyces cerevisiae

References / Literature

PMID:34375584 - A composite DNA element that functions as a maintainer required for epigenetic inheritance of heterochromatin.

Wang X et al. Mol Cell 2021 Oct 07;81(19):3979-3991.e4

PMID:12050156 - Surplus zinc is handled by Zym1 metallothionein and Zhf endoplasmic reticulum transporter in Schizosaccharomyces pombe.

Borrelly GP et al. J Biol Chem 2002 Aug 16;277(33):30394-400

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:18030666 - Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast.

Singh G et al. Yeast 2008 Feb;25(2):117-28

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24224056 - The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.

Kato H et al. PLoS One 2013;8(11):e80572

PMID:27664222 - A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.

He Y et al. Nucleic Acids Res 2017 Jan 09;45(1):106-114

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:15448137 - Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.

Davidson MK et al. J Biol Chem 2004 Dec 03;279(49):50857-63

PMID:25023750 - Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast.

Togashi N et al. BMC Microbiol 2014 Jul 15;14:188

PMID:40923761 - Intrinsically disordered region of Clr4/Suv39 regulates its enzymatic activity and ensures heterochromatin spreading.

Nakamura R et al. Nucleic Acids Res 2025 Sep 05;53(17)

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:12221110 - Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Greenall A et al. Mol Biol Cell 2002 Sep;13(9):2977-89

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:38252660 - Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.

Tsuruta Y et al. PLoS One 2024;19(1):e0294191

PMID:35360049 - Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe .

Basu S et al. Data Brief 2022 Jun;42:108034

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:28645196 - Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.

Bandyopadhyay S et al. FEMS Microbiol Lett 2017 Aug 01;364(14)

PMID:9585506 - Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast.

Gaits F et al. Genes Dev 1998 May 15;12(10):1464-73

PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647

PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14

PMID:15218150 - RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.

Jia S et al. Science 2004 Jun 25;304(5679):1971-6

PMID:16141205 - The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

Zuin A et al. J Biol Chem 2005 Nov 04;280(44):36708-13

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15

PMID:7958849 - A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity.

Wahls WP et al. Genes Dev 1994 Jul 15;8(14):1693-702

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:8552099 - Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development.

Watanabe Y et al. Mol Cell Biol 1996 Feb;16(2):704-11

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:28775286 - Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNA Lys UUU modifications.

Villahermosa D et al. Sci Rep 2017 Aug 03;7(1):7225

PMID:22160596 - Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Cherkasova V et al. Mol Biol Cell 2012 Feb;23(3):480-91

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:15475954 - RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing.

Noma K et al. Nat Genet 2004 Nov;36(11):1174-80

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:15164362 - Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress.

Paredes V et al. Yeast 2004 May;21(7):593-603

PMID:26567340 - Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P et al. J Biol Chem 2016 Jan 08;291(2):790-9

PMID:22144913 - Widespread cotranslational formation of protein complexes.

Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398

PMID:16914721 - Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Rodríguez-Gabriel MA et al. Mol Cell Biol 2006 Sep;26(17):6347-56

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:10102365 - Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast.

Ohmiya R et al. Mol Gen Genet 1999 Mar;261(2):297-306

PMID:15292231 - Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

Kim HS et al. J Biol Chem 2004 Oct 08;279(41):42850-9

PMID:16246721 - The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast.

Yamada T et al. Mol Cell 2005 Oct 28;20(2):173-85

PMID:18375616 - Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation.

Sansó M et al. Eukaryot Cell 2008 May;7(5):826-35

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:18252721 - Fission yeast MAP kinase Sty1 is recruited to stress-induced genes.

Reiter W et al. J Biol Chem 2008 Apr 11;283(15):9945-56

PMID:12855726 - Different roles for the stress-activated protein kinase pathway in the regulation of trehalose metabolism in Schizosaccharomyces pombe.

Paredes V et al. Microbiology (Reading) 2003 Jul;149(Pt 7):1745-1752

PMID:14633985 - RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.

Rodríguez-Gabriel MA et al. EMBO J 2003 Dec 01;22(23):6256-66

PMID:28652406 - Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C et al. J Biol Chem 2017 Aug 18;292(33):13635-13644

PMID:26443059 - Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.

Deng X et al. Sci Rep 2015 Oct 07;5:14707

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:35908934 - Euchromatin factors HULC and Set1C affect heterochromatin organization and mating-type switching in fission yeast Schizosaccharomyces pombe.

Esquivel-Chávez A et al. Genes Genet Syst 2022 Oct 18;97(3):123-138

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22733737 - Ers1 links HP1 to RNAi.

Rougemaille M et al. Proc Natl Acad Sci U S A 2012 Jul 10;109(28):11258-63

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71