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protein coding gene - tim10 (SPAC222.03c) - Tim9-Tim10 complex subunit Tim10

Gene summary

Standard name
tim10
Systematic ID
SPAC222.03c
Product
Tim9-Tim10 complex subunit Tim10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTE9
ORFeome ID
06/06H11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 947876..948652 reverse strand

Annotation

GO biological process

GO:7770063 - beta barrel protein insertion into mitochondrial outer membrane

References:

GO:7770061 - TOM-TIM22-mediated mitochondrial inner membrane protein insertion

References:

GO cellular component

GO:7770105 - Tim9-Tim10 complex

References:

GO molecular function

GO:0140309 - unfolded protein holdase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

Protein features

PBO:0111806 - zf-Tim10/DDP type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02953zf-Tim10_DDPTim10-likePfam
G3DSA:1.10.287.810:FF:000002CATH-FunFam
G3DSA:1.10.287.810Tim10-like_dom_sfCATH-Gene3D
SSF144122Tim10-like_dom_sfSUPERFAMILY
PTHR11038PANTHER

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30280012 - Crystal structure and functional analysis of human C1ORF123.
A Rahaman SN et al. PeerJ 2018;6:e5377
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:26182355 - Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1.
Spiller MP et al. Biosci Rep 2015 Mar 17;35(3)
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7