protein coding gene - yth1 (SPAC227.08c) - mRNA cleavage and polyadenylation specificity factor complex zinc finger subunit Yth1

Gene summary

Standard name: yth1
Systematic ID: SPAC227.08c
Product: mRNA cleavage and polyadenylation specificity factor complex zinc finger subunit Yth1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTD1
ORFeome ID: 07/07F09
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 510410..511364 reverse strand

Annotation

GO biological process

GO:0180010 - co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

References:

GO_REF:0000111

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex

References:

PMID:14617822

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0046872 - metal ion binding

References:

GO_REF:0000002

GO:0003723 - RNA binding

References:

GO_REF:0000002

Protein features

PBO:0111777 - zf-CCCH type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

PMID:23697806

Genotypes:

yth1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

yth1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00642	zf-CCCH	Znf_CCCH	PFAM
PS50103	ZF_C3H1	Znf_CCCH	PROSITE_PROFILES
SM00356	c3hfinal6	Znf_CCCH	SMART
G3DSA:4.10.1000.10:FF:000012			FUNFAM
SSF90229	CCCH zinc finger	Znf_CCCH_sf	SUPERFAMILY
G3DSA:4.10.1000.10			GENE3D
PTHR23102	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED	CPSF4/Yth1	PANTHER

Orthologs

CPSF4 (HGNC:2327) Homo sapiens
CPSF4L (HGNC:33632) Homo sapiens
yth1 (SJAG_00527) Schizosaccharomyces japonicus
YTH1 (YPR107C) Saccharomyces cerevisiae

References / Literature

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28367989 - The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.: Wittmann S et al. Nat Commun 2017 Apr 03;8:14861
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.: Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .: Budden AM et al. Elife 2023 Aug 24;12
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.: Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.: Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5
PMID:14617822 - A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.: Roguev A et al. Mol Cell Proteomics 2004 Feb;3(2):125-32
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference