protein coding gene - fol3 (SPAC227.09) - folylpolyglutamate synthase Fol3

Gene summary

Standard name: fol3
Systematic ID: SPAC227.09
Product: folylpolyglutamate synthase Fol3
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTD0
ORFeome ID: 20/20A03
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 511684..513382 forward strand

Annotation

GO biological process

GO:0006761 - dihydrofolate biosynthetic process

References:

GO_REF:0000108

GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process

References:

GO_REF:0000036

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0008841 - dihydrofolate synthase activity

References:

GO_REF:0000033

GO:0004326 - tetrahydrofolylpolyglutamate synthase activity

References:

GO_REF:0000033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

fol3delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

fol3delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF08245	Mur_ligase_M	Mur_ligase_cen	Pfam
PF27239	FOL3_C	FOL3_C	Pfam
G3DSA:3.40.1190.10:FF:000010			CATH-FunFam
G3DSA:3.90.190.20:FF:000010			CATH-FunFam
G3DSA:3.40.1190.10		Mur-like_cat_sf	CATH-Gene3D
G3DSA:3.90.190.20		Mur_ligase_C_dom_sf	CATH-Gene3D
SSF53244		Mur_ligase_C_dom_sf	SUPERFAMILY
SSF53623		Mur-like_cat_sf	SUPERFAMILY
PTHR11136		Folylpolyglutamate_synth	PANTHER
PIRSF001563	Folylpolyglu_synth	Folylpolyglutamate_synth	PIRSF
TIGR01499	folC	Folylpolyglutamate_synth	NCBIFAM

Orthologs

FPGS (HGNC:3824) Homo sapiens
fol3 (SJAG_00529) Schizosaccharomyces japonicus
RMA1 (YKL132C) Saccharomyces cerevisiae
FOL3 (YMR113W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000002 - Comments
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000036 - Manual annotations that require more than one source of functional data to support the assignment of the associated GO term
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36