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protein coding gene - rna4 (SPAC227.12) - U4/U6 x U5 tri-snRNP complex WD repeat subunit Rna4

Gene summary

Standard name
rna4
Systematic ID
SPAC227.12
Product
U4/U6 x U5 tri-snRNP complex WD repeat subunit Rna4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
prp4
UniProt ID
Q9UTC7
ORFeome ID
23/23D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 515794..517504 forward strand

Annotation

Disease association

MONDO:0014400 - retinitis pigmentosa 70

References:

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO molecular function

GO:0030621 - U4 snRNA binding

References:

GO:0017070 - U6 snRNA binding

References:

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00400WD40WD40_rptPfam
PF08799PRP4PRP4-likePfam
cd00200WD40CDD
PS00678WD_REPEATS_1WD40_repeat_CSPROSITE patterns
PS50082WD_REPEATS_2WD40_rptPROSITE profiles
PS50294WD_REPEATS_REGIONPROSITE profiles
SM00320WD40WD40_rptSMART
SM00500SFMPRP4-likeSMART
PR00320GPROTEINBRPTWD40_PAC1PRINTS
G3DSA:2.130.10.10:FF:000411CATH-FunFam
G3DSA:4.10.280.110:FF:000015CATH-FunFam
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfCATH-Gene3D
G3DSA:4.10.280.110PRP4-like_sfCATH-Gene3D
SSF158230PRP4-like_sfSUPERFAMILY
SSF50978WD40_repeat_dom_sfSUPERFAMILY
PTHR19846PANTHER

Orthologs

References / Literature

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.
Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.
Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87
PMID:18948543 - Splicing factors facilitate RNAi-directed silencing in fission yeast.
Bayne EH et al. Science 2008 Oct 24;322(5901):602-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7