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protein coding gene - pig25 (SPAC227.19c) - pig-Y, phosphatidylinositol N-acetylglucosaminyltransferase subunit

Gene summary

Standard name
pig25
Systematic ID
SPAC227.19c
Product
pig-Y, phosphatidylinositol N-acetylglucosaminyltransferase subunit
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNCRNA.85
UniProt ID
C6Y4B7
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 501117..501485 reverse strand

Annotation

Disease association

MONDO:0014780 - hyperphosphatasia with intellectual disability syndrome 6

References:

GO biological process

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0000506 - glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

References:

GO molecular function

GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

References:

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

References:

PBO:0011070 - conserved in vertebrates

References:

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

PBO:0000406 - previously annotated as ncRNA

Protein features

IDNameInterPro nameDB name
PF15159PIG-YPIG-YPfam
PTHR39400PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
Pfam:PF15159 - Unknown title
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs