protein coding gene - rpc11 (SPAC22A12.05) - DNA-directed RNA polymerase III complex subunit Rpc11

Gene summary

Standard name

rpc11

Systematic ID

SPAC22A12.05

Product

DNA-directed RNA polymerase III complex subunit Rpc11

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13896

ORFeome ID

01/01H01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1163049..1163522 forward strand

Annotation

Protein features

Orthologs

• POLR3K (HGNC:14121) Homo sapiens
• rpc11 (SJAG_03761) Schizosaccharomyces japonicus
• RPC11 (YDR045C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.

Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15632064 - Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.

Huang Y et al. Mol Cell Biol 2005 Jan;25(2):621-36

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

GO_REF:0000002 - Comments

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.

Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:21450810 - Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III.

Iben JR et al. Nucleic Acids Res 2011 Aug;39(14):6100-13

PMID:18044988 - Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.

Yee NS et al. PLoS Biol 2007 Nov;5(11):e312

PMID:21572561 - 3' processing of eukaryotic precursor tRNAs.

Maraia RJ et al. Wiley Interdiscip Rev RNA 2011;2(3):362-75

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:25447915 - A methods review on use of nonsense suppression to study 3' end formation and other aspects of tRNA biogenesis.

Rijal K et al. Gene 2015 Feb 01;556(1):35-50