protein coding gene - SPAC22E12.02 - splicing factor, WW domain -binding Rbm42

Gene summary

Systematic ID: SPAC22E12.02
Product: splicing factor, WW domain -binding Rbm42
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q10355
ORFeome ID: 12/12B11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 5021990..5024151 forward strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO_REF:0000024

GO cellular component

GO:0005634 - nucleus

References:

PMID:16823372

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO_REF:0000024

GO molecular function

GO:0003729 - mRNA binding

References:

GO_REF:0000033

Modification

MOD:00006 - N-glycosylated residue

References:

PMID:22633491

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein features

PBO:0111764 - rrm RNA recognition motif

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

SPAC22E12.02delta

FYPO:0000741 - increased cellular pigment accumulation

References:

PMID:23697806

Genotypes:

SPAC22E12.02delta

FYPO:0001490 - inviable elongated vegetative cell

References:

PMID:23697806

Genotypes:

SPAC22E12.02delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

SPAC22E12.02delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00076	RRM_1	RRM_dom	PFAM
cd12383	RRM_RBM42	RBM42_RRM	CDD
PS50102	RRM	RRM_dom	PROSITE_PROFILES
SM00360	rrm1_1	RRM_dom	SMART
G3DSA:3.30.70.330:FF:001581			FUNFAM
SSF54928	RNA-binding domain, RBD	RBD_domain_sf	SUPERFAMILY
G3DSA:3.30.70.330		Nucleotide-bd_a/b_plait_sf	GENE3D
PTHR47640	TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED	RBM42_RBP45_47-like	PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Low-complexity	disorder_prediction		MOBIDB-Low-complexity
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar
mobidb-lite-Positive-Polyelectrolyte	disorder_prediction		MOBIDB-Positive-Polyelectrolyte

Orthologs

RBM42 (HGNC:28117) Homo sapiens
SJAG_04405 Schizosaccharomyces japonicus

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.: Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;