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protein coding gene - rna1 (SPAC22E12.07) - RanGAP Rna1

Gene summary

Standard name
rna1
Systematic ID
SPAC22E12.07
Product
RanGAP Rna1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P41391
ORFeome ID
18/18C11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5031771..5033261 forward strand

Annotation

GO biological process

GO:0006611 - protein export from nucleus

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0034399 - nuclear periphery

References:

GO:0005634 - nucleus

References:

GO:0048471 - perinuclear region of cytoplasm

References:

GO molecular function

GO:0005096 - GTPase activator activity

References:

GO:0031267 - small GTPase binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111865 - leucine-rich repeat protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000664 - abolished catalytic activity

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Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
cd00116LRR_RICDD
SM00368LRR_RISMART
G3DSA:3.80.10.10LRR_dom_sfCATH-Gene3D
SSF52047SUPERFAMILY
PTHR24113RanGapPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:16540522 - Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.
Nishijima H et al. Mol Biol Cell 2006 Jun;17(6):2524-36
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:18422602 - Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
Ohba T et al. Genes Cells 2008 Jun;13(6):571-82
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16790931 - Detecting and overcoming hemihedral twinning during the MIR structure determination of Rna1p.
Hillig RC et al. Acta Crystallogr D Biol Crystallogr 2006 Jul;62(Pt 7):750-65
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:10394366 - The crystal structure of rna1p: a new fold for a GTPase-activating protein.
Hillig RC et al. Mol Cell 1999 Jun;3(6):781-91
PMID:15317843 - Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.
Kusano A et al. Mol Biol Cell 2004 Nov;15(11):4960-70
PMID:7805886 - Recombinant expression and domain structure of the Rna1 protein from Schizosaccharomyces pombe.
Haberland J et al. FEBS Lett 1995 Jan 03;357(2):173-7
PMID:8374168 - A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.
Melchior F et al. Mol Biol Cell 1993 Jun;4(6):569-81
PMID:8887664 - Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.
Matynia A et al. Mol Cell Biol 1996 Nov;16(11):6352-62
PMID:9504913 - The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein.
He X et al. Genetics 1998 Feb;148(2):645-56
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:11832950 - RanGAP mediates GTP hydrolysis without an arginine finger.
Seewald MJ et al. Nature 2002 Feb 07;415(6872):662-6
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7