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protein coding gene - alp41 (SPAC22F3.05c) - tubulin specific chaperone, GTP-binding protein, Alp41

Gene summary

Standard name
alp41
Systematic ID
SPAC22F3.05c
Product
tubulin specific chaperone, GTP-binding protein, Alp41
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09767
ORFeome ID
09/09F10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 697286..703040 forward strand

Annotation

Disease association

MONDO:0033644 - microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1

References:

GO biological process

GO:0006457 - protein folding

References:

GO:0007021 - tubulin complex assembly

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GO cellular component

GO:0005829 - cytosol

References:

GO:0015630 - microtubule cytoskeleton

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GO:0005634 - nucleus

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GO molecular function

GO:0005525 - GTP binding

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GO:0003924 - GTPase activity

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GO:0005515 - protein binding

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Modification

MOD:00068 - N-myristoylglycine

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Multi-locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000338 - abnormal mitotic spindle

References:

Genotypes:

FYPO:0000016 - curved vegetative cell

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

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Genotypes:

FYPO:0004518 - inviable after spore germination, multiple cell divisions, branched, curved, elongated cell

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Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002004 - microtubules absent from cell

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00025ArfSmall_GTPase_ARF/SARPFAM
cd04154Arl2Arl2CDD
PS51417ARFPROSITE_PROFILES
SM00177arf_sub_2SMART
SM00175rab_sub_5SMART
SM00178sar_sub_1Small_GTPase_ARF/SARSMART
PR00328SAR1GTPBPSmall_GTPase_ARF/SARPRINTS
G3DSA:3.40.50.300:FF:001166FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR45697ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATEDARL2/3PANTHER
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37403782 - The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA.
Porat J et al. Nucleic Acids Res 2023 Sep 08;51(16):8805-8819
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
GO_REF:0000002 - Comments
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:10683446 - A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast.
Radcliffe PA et al. FEBS Lett 2000 Feb 18;468(1):84-8
PMID:23576550 - The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.
Mori R et al. Mol Biol Cell 2013 Jun;24(11):1713-24, S1-8