protein coding gene - rgs1 (SPAC22F3.12c) - regulator of G-protein signaling Rgs1

Gene summary

Standard name

rgs1

Systematic ID

SPAC22F3.12c

Product

regulator of G-protein signaling Rgs1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09777

ORFeome ID

23/23C06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 679803..681890 forward strand

Annotation

Protein features

Orthologs

• rgs1 (SJAG_00990) Schizosaccharomyces japonicus
• SST2 (YLR452C) Saccharomyces cerevisiae

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:19285552 - Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.

Smith B et al. Cell Signal 2009 Jul;21(7):1151-60

PMID:23200991 - Cdc42 explores the cell periphery for mate selection in fission yeast.

Bendezú FO et al. Curr Biol 2013 Jan 07;23(1):42-7

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.

Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23900842 - A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.

Croft W et al. J Biol Chem 2013 Sep 20;288(38):27327-27342

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:24167631 - Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase.

Shimanuki M et al. PLoS One 2013;8(10):e78545

PMID:10417652 - An RGS protein regulates the pheromone response in the fission yeast Schizosaccharomyces pombe.

Watson P et al. Mol Microbiol 1999 Aug;33(3):623-34

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:12172965 - Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

Didmon M et al. Curr Genet 2002 Jul;41(4):241-53

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17032641 - Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Mata J et al. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15517-22

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.

Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.

Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802