protein coding gene - tsc1 (SPAC22F3.13) - Rheb GAP, hamartin Tsc1

Gene summary

Standard name

tsc1

Systematic ID

SPAC22F3.13

Product

Rheb GAP, hamartin Tsc1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09778

ORFeome ID

39/39A02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 673984..678259 reverse strand

Annotation

Protein features

Orthologs

• TSC1 (HGNC:12362) Homo sapiens
• tsc1 (SJAG_00991) Schizosaccharomyces japonicus

References / Literature

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:17179073 - Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.

Weisman R et al. Genetics 2007 Mar;175(3):1153-62

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:14718525 - Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2004 Mar 26;279(13):12706-13

PMID:23813957 - The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.

Nakase Y et al. J Cell Sci 2013 Sep 01;126(Pt 17):3972-81

PMID:25639242 - Nitrogen regulates AMPK to control TORC1 signaling.

Davie E et al. Curr Biol 2015 Feb 16;25(4):445-54

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:11751918 - The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Taricani L et al. J Biol Chem 2002 Mar 22;277(12):10562-72

PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.

Chia KH et al. Elife 2017 Dec 04;6

PMID:17121544 - Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Uritani M et al. Genes Cells 2006 Dec;11(12):1367-79

PMID:16115814 - Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M et al. Hum Mol Genet 2005 Oct 01;14(19):2851-8

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Murai T et al. Genetics 2009 Oct;183(2):517-27

PMID:17556368 - The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2007 Aug 24;282(34):24583-90

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23857276 - Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.

Sun W et al. Nat Commun 2013;4:2135

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:29343513 - Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function.

Rayhan A et al. Biol Open 2018 Jan 17;7(1)

PB_REF:0000003 - Disease Association Curation

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:33534698 - Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.

Fukuda T et al. Elife 2021 Feb 03;10

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:30814334 - Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling.

Forte GM et al. J Cell Sci 2019 Apr 03;132(7)

PMID:22160596 - Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Cherkasova V et al. Mol Biol Cell 2012 Feb;23(3):480-91

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Nakase Y et al. Genetics 2006 Jun;173(2):569-78

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:34028542 - TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.

Toyoda Y et al. J Cell Sci 2021 May 15;134(10)

GO_REF:0000051 - S. pombe keyword mapping

PMID:12136010 - Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.

Matsumoto S et al. Genetics 2002 Jul;161(3):1053-63

PMID:24344203 - Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Laor D et al. Mol Cell Biol 2014 Mar;34(5):794-806