PomBase - protein coding gene - pam1 (SPAC22F8.06) - 20S proteasome complex subunit beta 6 Pam1 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF00227	Proteasome	Proteasome_sua/b	PFAM
cd03757	proteasome_beta_type_1		CDD
PS00854	PROTEASOME_BETA_1	Proteasome_bsu_CS	PROSITE_PATTERNS
PS51476	PROTEASOME_BETA_2	Proteasome_suB-type	PROSITE_PROFILES
G3DSA:3.60.20.10:FF:000027			FUNFAM
SSF56235	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Ntn_hydrolases_N	SUPERFAMILY
G3DSA:3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Ntn_hydrolases_N	GENE3D
PTHR32194	METALLOPROTEASE TLDD	Proteasome_suB-type	PANTHER

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21098295 - Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.: Bohn S et al. Proc Natl Acad Sci U S A 2010 Dec 07;107(49):20992-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24938783 - Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.: Leitner A et al. Proc Natl Acad Sci U S A 2014 Jul 01;111(26):9455-60
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.: Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.: Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.: Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.: Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.: Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.: Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

protein coding gene - pam1 (SPAC22F8.06) - 20S proteasome complex subunit beta 6 Pam1

Gene summary

Annotation

Disease association

MONDO:0859287 - neurodevelopmental disorder with microcephaly, hypotonia, and absent language

GO biological process

GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

GO cellular component

GO:0005829 - cytosol

GO:0005634 - nucleus

GO:0019774 - proteasome core complex, beta-subunit complex

GO molecular function

GO:0004175 - endopeptidase activity

Modification

MOD:00046 - O-phospho-L-serine

MOD:01148 - ubiquitinylated lysine

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

FYPO:0002151 - inviable spore

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature