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protein coding gene - rtf1 (SPAC22F8.07c) - RNA polymerase I termination factor Rtf1

Gene summary

Standard name
rtf1
Systematic ID
SPAC22F8.07c
Product
RNA polymerase I termination factor Rtf1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UUI6
ORFeome ID
45/45E04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4797195..4799127 reverse strand

Annotation

GO biological process

GO:0071171 - site-specific DNA replication termination at RTS1 barrier

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0031634 - replication fork barrier binding

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Multi-locus phenotype

FYPO:0003084 - abolished replication fork arrest at mating-type locus

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Genotypes:

FYPO:0003085 - decreased replication fork arrest at mating-type locus

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Genotypes:

FYPO:0005353 - normal replication fork arrest at RTS1 barrier

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Genotypes:

FYPO:0005360 - reversed RTS1 barrier polarity

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Genotypes:

Protein features

PBO:0111844 - Myb family

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003084 - abolished replication fork arrest at mating-type locus

References:

Genotypes:

FYPO:0003352 - decreased DNA double-strand break formation at mating-type locus

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Genotypes:

FYPO:0003085 - decreased replication fork arrest at mating-type locus

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Genotypes:

FYPO:0006603 - decreased replication fork arrest at RTS1 barrier

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Genotypes:

FYPO:0000657 - increased DNA binding

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Genotypes:

FYPO:0007679 - increased replication fork arrest at RTS1 barrier

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Genotypes:

FYPO:0005358 - increased site-specific DNA replication termination at RTS1 barrier

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Genotypes:

FYPO:0005353 - normal replication fork arrest at RTS1 barrier

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Genotypes:

FYPO:0005359 - normal termination of RNA polymerase II transcription at RTS1 barrier

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000077 - resistance to rapamycin

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00249Myb_DNA-bindingSANT/MybPfam
PF21559Reb1_MybADREB1_MybADPfam
cd00167SANTSANT/MybCDD
PS50090MYB_LIKESANT/MybPROSITE profiles
PS51294HTH_MYBMyb_domPROSITE profiles
SM00717SANTSANT/MybSMART
G3DSA:1.10.10.60:FF:000387CATH-FunFam
G3DSA:1.10.10.60CATH-Gene3D
SSF46689Homeodomain-like_sfSUPERFAMILY
PTHR46380DMTF1_REB1PANTHER

Orthologs

References / Literature

PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:32366382 - Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms.
Chen JJ et al. Mol Cell Biol 2020 Jul 14;40(15)
PMID:12840005 - Complex mechanism of site-specific DNA replication termination in fission yeast.
Codlin S et al. EMBO J 2003 Jul 01;22(13):3431-40
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:18723894 - Rtf1-mediated eukaryotic site-specific replication termination.
Eydmann T et al. Genetics 2008 Sep;180(1):27-39
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
EMBL:AJ627891 - Unknown title
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:33568651 - Replication dynamics of recombination-dependent replication forks.
Naiman K et al. Nat Commun 2021 Feb 10;12(1):923
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .
Budden AM et al. Elife 2023 Aug 24;12
PMID:25776556 - The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity.
Akamatsu Y et al. Mol Cell Biol 2015 May;35(10):1871-81
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704