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protein coding gene - sec24 (SPAC22F8.08) - COPII vesicle coat cargo adaptor Sec24

Gene summary

Standard name
sec24
Systematic ID
SPAC22F8.08
Product
COPII vesicle coat cargo adaptor Sec24
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sfb2
UniProt ID
Q9UUI5
ORFeome ID
29/29D08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4799595..4802652 forward strand

Annotation

GO biological process

GO:0090110 - COPII-coated vesicle cargo loading

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0005801 - cis-Golgi network

References:

GO:0030127 - COPII vesicle coat

References:

GO:0005829 - cytosol

References:

GO:0070971 - endoplasmic reticulum exit site

References:

GO:1990753 - equatorial cell cortex

References:

GO molecular function

GO:0140312 - cargo adaptor activity

References:

GO:0000149 - SNARE binding

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00626GelsolinGelsolin-like_domPfam
PF04810zf-Sec23_Sec24Znf_Sec23_Sec24Pfam
PF04811Sec23_trunkSec23/24_trunk_domPfam
PF04815Sec23_helicalSec23/24_helical_domPfam
PF08033Sec23_BSBeta-sandwich_Sec23_24Pfam
cd01479Sec24-likeSec24-like_trunk_domCDD
G3DSA:1.20.120.730CATH-Gene3D
G3DSA:2.30.30.380CATH-Gene3D
G3DSA:2.60.40.1670CATH-Gene3D
G3DSA:3.40.20.10ADF-H/Gelsolin-like_dom_sfCATH-Gene3D
G3DSA:3.40.50.410vWFA_dom_sfCATH-Gene3D
SSF53300vWFA_dom_sfSUPERFAMILY
SSF81811Sec23/24_helical_dom_sfSUPERFAMILY
SSF81995SUPERFAMILY
SSF82754Gelsolin-like_dom_sfSUPERFAMILY
SSF82919Znf_Sec23_Sec24_sfSUPERFAMILY
PTHR13803SEC23_SEC24_subfamilyPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.
Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:27855785 - Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation.
Davis S et al. Elife 2016 Nov 18;5
PMID:18184749 - The actomyosin ring recruits early secretory compartments to the division site in fission yeast.
Vjestica A et al. Mol Biol Cell 2008 Mar;19(3):1125-38
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:40114852 - Characterization and comparison of Schizosaccharomyces pombe cdc15 temperature-sensitive mutants.
Turner LA et al. MicroPubl Biol 2025;2025
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:41676957 - Trafficking of the human Na + /H + antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors.
Kacovská K et al. Protein Sci 2026 Mar;35(3):e70492
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405