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protein coding gene - fra1 (SPAC22G7.01c) - iron responsive transcriptional regulator, peptidase family

Gene summary

Standard name
fra1
Systematic ID
SPAC22G7.01c
Product
iron responsive transcriptional regulator, peptidase family
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAPJ696.03c, ppp51
UniProt ID
Q09795
ORFeome ID
27/27D04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 725865..728245 reverse strand

Annotation

Disease association

MONDO:0100003 - susceptibility to angioedema induced by ACE inhibitors

References:

GO biological process

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0070006 - metalloaminopeptidase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000668 - decreased peptidase activity

References:

Genotypes:

FYPO:0005639 - normal RNA level during cellular response to iron ion starvation

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000668 - decreased peptidase activity

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0005639 - normal RNA level during cellular response to iron ion starvation

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00557Peptidase_M24Pept_M24Pfam
PF01321Creatinase_NCreatinase_NPfam
PF16188Peptidase_M24_CPeptidase_M24_CPfam
PF16189Creatinase_N_2Pfam
cd01085APPPept_M24BCDD
PS00491PROLINE_PEPTIDASEPeptidase_M24B_aminopep-P_CSPROSITE patterns
G3DSA:3.40.350.10:FF:000003CATH-FunFam
G3DSA:3.90.230.10:FF:000007CATH-FunFam
G3DSA:3.40.350.10Creatin/AminoP/Spt16_NCATH-Gene3D
G3DSA:3.90.230.10Creatinase/aminopeptidase-likeCATH-Gene3D
SSF53092Creatin/AminoP/Spt16_NSUPERFAMILY
SSF55920Creatinase/aminopeptidase-likeSUPERFAMILY
PTHR43763X-Pro_aminopeptidase_PPANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24897379 - Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.
Jacques JF et al. PLoS One 2014;9(6):e98959
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16802154 - Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe.
Idiris A et al. Appl Microbiol Biotechnol 2006 Nov;73(2):404-20
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7