protein coding gene - scd2 (SPAC22H10.07) - Cdc42 GTPase complex scaffold subunit Scd2

Gene summary

Standard name

scd2

Systematic ID

SPAC22H10.07

Product

Cdc42 GTPase complex scaffold subunit Scd2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ral3

UniProt ID

P40996

ORFeome ID

34/34H02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2382504..2385153 forward strand

Annotation

Protein features

Orthologs

• SH3PXD2A (HGNC:23664) Homo sapiens
• SH3PXD2B (HGNC:29242) Homo sapiens
• scd2 (SJAG_01794) Schizosaccharomyces japonicus
• BEM1 (YBR200W) Saccharomyces cerevisiae

References / Literature

PMID:21849474 - Spatial control of Cdc42 activation determines cell width in fission yeast.

Kelly FD et al. Mol Biol Cell 2011 Oct;22(20):3801-11

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:7923372 - Cooperative interaction of S. pombe proteins required for mating and morphogenesis.

Chang EC et al. Cell 1994 Oct 07;79(1):131-41

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:31719163 - A novel interplay between GEFs orchestrates Cdc42 activity during cell polarity and cytokinesis in fission yeast.

Hercyk BS et al. J Cell Sci 2019 Dec 03;132(23)

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:9892665 - Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation.

Chen CR et al. Proc Natl Acad Sci U S A 1999 Jan 19;96(2):517-22

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.

Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928

PMID:25837586 - Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.

Bendezú FO et al. PLoS Biol 2015 Apr;13(4):e1002097

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:11483497 - Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions.

Ito T et al. EMBO J 2001 Aug 01;20(15):3938-46

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27022830 - Microscopy of Fission Yeast Sexual Lifecycle.

Vjestica A et al. J Vis Exp 2016 Mar 09;(109)

PMID:23200991 - Cdc42 explores the cell periphery for mate selection in fission yeast.

Bendezú FO et al. Curr Biol 2013 Jan 07;23(1):42-7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:10574765 - Mis-specification of cortical identity in a fission yeast PAK mutant.

Sawin KE et al. Curr Biol 1999 Nov 18;9(22):1335-8

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:8943016 - The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

Gilbreth M et al. Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13802-7

PMID:9182664 - Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe.

Kitayama C et al. J Cell Biol 1997 Jun 16;137(6):1309-19

PMID:9679144 - Regulation of cell polarity by microtubules in fission yeast.

Sawin KE et al. J Cell Biol 1998 Jul 27;142(2):457-71

GO_REF:0000002 - Comments

PMID:15631622 - Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding.

Wheatley E et al. Biochem J 2005 May 15;388(Pt 1):177-84

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:10567532 - Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2.

Chang E et al. Mol Cell Biol 1999 Dec;19(12):8066-74

PMID:12409291 - The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.

Endo M et al. J Biol Chem 2003 Jan 10;278(2):843-52

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:41335110 - High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation.

Thomas V et al. J Cell Biol 2026 Feb 02;225(2)

PMID:30279276 - Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.

Gallo Castro D et al. J Cell Biol 2018 Dec 03;217(12):4215-4229

PMID:3071741 - Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1-.

Fukui Y et al. Mol Gen Genet 1988 Dec;215(1):26-31

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:9133664 - The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.

Hakuno F et al. Genes Cells 1996 Mar;1(3):303-15

PMID:19710424 - Pob1 participates in the Cdc42 regulation of fission yeast actin cytoskeleton.

Rincón SA et al. Mol Biol Cell 2009 Oct;20(20):4390-9

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:9660817 - Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast.

Yang P et al. J Biol Chem 1998 Jul 17;273(29):18481-9

PMID:39012625 - Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback.

Harrell MA et al. J Cell Biol 2024 Sep 02;223(10)