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protein coding gene - ala1 (SPAC23C11.09) - mitochondrial and cytoplasmic alanine-tRNA ligase Ala1

Gene summary

Standard name
ala1
Systematic ID
SPAC23C11.09
Product
mitochondrial and cytoplasmic alanine-tRNA ligase Ala1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ars1
UniProt ID
O13914
ORFeome ID
29/29F10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2147186..2150190 forward strand

Annotation

Disease association

MONDO:0015626 - Charcot-Marie-Tooth disease

References:

MONDO:0013212 - Charcot-Marie-Tooth disease axonal type 2N

References:

MONDO:0013570 - combined oxidative phosphorylation defect type 8

References:

MONDO:0014593 - developmental and epileptic encephalopathy, 29

References:

MONDO:0030634 - leukoencephalopathy, hereditary diffuse, with spheroids 2

References:

MONDO:0014387 - leukoencephalopathy, progressive, with ovarian failure

References:

MONDO:0005071 - nervous system disorder

References:

MONDO:0030517 - trichothiodystrophy 8, nonphotosensitive

References:

MONDO:0018614 - undetermined early-onset epileptic encephalopathy

References:

GO biological process

GO:0106074 - aminoacyl-tRNA metabolism involved in translational fidelity

References:

GO:0070127 - tRNA aminoacylation for mitochondrial protein translation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0004813 - alanine-tRNA ligase activity

References:

GO:0002161 - aminoacyl-tRNA deacylase activity

References:

GO:0005524 - ATP binding

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01411tRNA-synt_2cAla-tRNA-synth_IIc_NPfam
PF02272DHHA1DHHA1_domPfam
PF07973tRNA_SADtRNA_SADPfam
PF26023ALA1ALA1_helicalPfam
cd00673AlaRS_coreCDD
PS50860AA_TRNA_LIGASE_II_ALAAla-tRNA-synth_IIc_corePROSITE profiles
SM00863tRNA_SADtRNA_SADSMART
PR00980TRNASYNTHALAAla-tRNA-lgiase_IIcPRINTS
G3DSA:2.40.30.130:FF:000004CATH-FunFam
G3DSA:3.10.310.40:FF:000003CATH-FunFam
G3DSA:3.30.930.10:FF:000011CATH-FunFam
G3DSA:3.30.980.10:FF:000004CATH-FunFam
G3DSA:2.40.30.130CATH-Gene3D
G3DSA:3.10.310.40CATH-Gene3D
G3DSA:3.30.930.10aa-tRNA-synth_II/BPL/LPLCATH-Gene3D
G3DSA:3.30.980.10CATH-Gene3D
SSF101353Ala-tRNA-ligase_IIc_anticod-bdSUPERFAMILY
SSF50447Transl_B-barrel_sfSUPERFAMILY
SSF55186Thr/Ala-tRNA-synth_IIc_editSUPERFAMILY
SSF55681aa-tRNA-synth_II/BPL/LPLSUPERFAMILY
PTHR11777Ala-tRNA-lgiase_IIcPANTHER
TIGR00344alaSAla-tRNA-lgiase_IIcNCBIFAM
CoilCOILS
MF_00036_BAla_tRNA_synth_BAla_tRNA_ligase_euk/bacHAMAP

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PB_REF:0000003 - Disease Association Curation
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.
Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
GO_REF:0000002 - Comments
GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.
PMID:23293578 - Molecular genetics of charcot-marie-tooth disease: from genes to genomes.
Azzedine H et al. Mol Syndromol 2012 Nov;3(5):204-14
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.