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protein coding gene - cka1 (SPAC23C11.11) - serine/threonine protein kinase Cka1

Gene summary

Standard name
cka1
Systematic ID
SPAC23C11.11
Product
serine/threonine protein kinase Cka1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
orb5
UniProt ID
P40231
ORFeome ID
21/21B12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2152037..2154223 forward strand

Annotation

Disease association

MONDO:0014893 - Okur-Chung neurodevelopmental syndrome

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GO biological process

GO:0006974 - DNA damage response

References:

GO:0007163 - establishment or maintenance of cell polarity

References:

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO:2000247 - positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

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GO:2000099 - regulation of establishment or maintenance of bipolar cell polarity

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GO:0048024 - regulation of mRNA splicing, via spliceosome

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GO:0023052 - signaling

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GO cellular component

GO:0051286 - cell tip

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GO:0000785 - chromatin

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GO:0005829 - cytosol

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GO:0000935 - division septum

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GO:0044732 - mitotic spindle pole body

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GO:0005730 - nucleolus

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GO:0005634 - nucleus

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GO:0005956 - protein kinase CK2 complex

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GO:0034456 - UTP-C complex

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GO molecular function

GO:0005524 - ATP binding

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GO:0004674 - protein serine/threonine kinase activity

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Modification

MOD:00006 - N-glycosylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002700 - increased protein kinase activity

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0000839 - inviable elongated mononucleate aseptate cell

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Genotypes:

FYPO:0004106 - inviable multinucleate aseptate vegetative cell

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Genotypes:

FYPO:0001294 - normal actin cortical patch localization

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Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0003503 - normal vegetative cell length

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Genotypes:

FYPO:0001119 - tapered vegetative cell

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Genotypes:

Protein features

PBO:0111856 - CK2 subfamily

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001418 - abnormal microtubule cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0004105 - abolished polar cell growth

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Genotypes:

FYPO:0005739 - complete but unequal mitotic sister chromatid segregation with unseparated chromosomes

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Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

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Genotypes:

FYPO:0001382 - decreased protein kinase activity

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

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Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

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Genotypes:

FYPO:0004791 - increased telomere-nuclear envelope distance during mitotic G2 phase

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

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Genotypes:

FYPO:0002000 - inviable septated mononucleate vegetative cell

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Genotypes:

FYPO:0004104 - inviable spherical vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001125 - normal vegetative cell shape

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Genotypes:

FYPO:0001696 - sensitive to protein kinase inhibitor

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Genotypes:

FYPO:0000129 - spherical vegetative cell

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Genotypes:

FYPO:0000024 - stubby vegetative cell

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Genotypes:

FYPO:0000647 - vegetative cell lysis

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Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPFAM
cd14132STKc_CK2_alphaCK2_alphaCDD
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE_PATTERNS
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE_PATTERNS
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE_PROFILES
SM00220serkin_6Prot_kinase_domSMART
G3DSA:1.10.510.10:FF:000459FUNFAM
G3DSA:3.30.200.20:FF:000088FUNFAM
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:3.30.200.20Phosphorylase Kinase; domain 1GENE3D
G3DSA:1.10.510.10Transferase(Phosphotransferase) domain 1GENE3D
PTHR24054CASEIN KINASE II SUBUNIT ALPHACK2_alphaPANTHER

Orthologs

References / Literature

PMID:34209806 - Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
Mikolaskova B et al. Int J Mol Sci 2021 Jun 29;22(13)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25410910 - Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe.
Moreira-Ramos S et al. FEBS J 2015 Feb;282(3):491-503
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20536828 - A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe.
Roux AE et al. Ann N Y Acad Sci 2010 Jun;1197:19-27
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.
Inoue H et al. Genes Cells 2017 Jan;22(1):59-70
PMID:34674264 - Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.
Chen JS et al. FEBS Lett 2021 Nov;595(22):2781-2792
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23986474 - Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
Tay YD et al. J Cell Sci 2013 Nov 01;126(Pt 21):5052-61
PMID:32878942 - Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment.
Bohnert KA et al. J Cell Sci 2020 Sep 17;133(18)
PMID:8264625 - The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit.
Roussou I et al. Mol Cell Biol 1994 Jan;14(1):576-86
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19136623 - Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.
Shimada A et al. Genes Dev 2009 Jan 01;23(1):18-23
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000051 - S. pombe keyword mapping
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:30635402 - Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
Nakazawa N et al. J Biol Chem 2019 Mar 08;294(10):3772-3782
PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46
PMID:19646873 - The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
Das M et al. Curr Biol 2009 Aug 11;19(15):1314-9
PMID:25332400 - N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.
Nishibuchi G et al. Nucleic Acids Res 2014 Nov 10;42(20):12498-511
PMID:31131414 - Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.
Inoue H et al. Nucleic Acids Res 2019 Jul 26;47(13):6871-6884
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:22683458 - Interacting factors and cellular localization of SR protein-specific kinase Dsk1.
Tang Z et al. Exp Cell Res 2012 Oct 01;318(16):2071-84
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16049013 - Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast.
Shimada M et al. J Biol Chem 2005 Sep 23;280(38):32640-8
PMID:23462181 - Crosstalk between casein kinase II and Ste20-related kinase Nak1.
Cipak L et al. Cell Cycle 2013 Mar 15;12(6):884-8
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:33836577 - A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Zdravković A et al. Proc Natl Acad Sci U S A 2021 Mar 16;118(11)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
GO_REF:0000002 - Comments
PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.
Snell V et al. EMBO J 1994 May 01;13(9):2066-74
PMID:40700808 - Exploring the Cka1 kinase interactome: unveiling novel potential regulatory roles of CKII kinase in S. pombe.
Jurcik J et al. Biochem Biophys Res Commun 2025 Jul 17;778:152382