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protein coding gene - plo1 (SPAC23C11.16) - Polo kinase Plo1

Gene summary

Standard name
plo1
Systematic ID
SPAC23C11.16
Product
Polo kinase Plo1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P50528
ORFeome ID
27/27F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2164231..2166765 forward strand

Annotation

Comment

PBO:0001387 - function depends on a functional spindle assembly checkpoint

References:

PBO:0001386 - function depends on recruitment to the spindle pole body

References:

PBO:0024819 - promoter contains PCB

References:

PBO:0001385 - stress response pathway signalling (SRP), mediated phosphorylation of Ser402 ensures efficient reinitiation of tip growth and cell division during recovery from particular stress

References:

PBO:0001384 - stress response pathway signalling (SRP), mediated phosphorylation of Ser402 regulates the timing of commitment to mitosis

References:

GO biological process

GO:0031619 - homologous chromosome orientation in meiotic metaphase I

References:

GO:0045143 - homologous chromosome segregation

References:

GO:0035556 - intracellular signal transduction

References:

GO:1990571 - meiotic centromere clustering

References:

GO:1990813 - meiotic centromeric cohesion protection in anaphase I

References:

GO:1990395 - meiotic spindle pole body organization

References:

GO:0007052 - mitotic spindle organization

References:

GO:0045793 - positive regulation of cell size

References:

GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

References:

GO:1903501 - positive regulation of mitotic actomyosin contractile ring assembly

References:

GO:1903490 - positive regulation of mitotic cytokinesis

References:

GO:0045842 - positive regulation of mitotic metaphase/anaphase transition

References:

GO:0140429 - positive regulation of mitotic sister chromatid biorientation

References:

GO:0046827 - positive regulation of protein export from nucleus

References:

GO:0031031 - positive regulation of septation initiation signaling

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0051455 - spindle attachment to meiosis I kinetochore

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0000776 - kinetochore

References:

GO:0072687 - meiotic spindle

References:

GO:0090619 - meiotic spindle pole

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0072686 - mitotic spindle

References:

GO:1990023 - mitotic spindle midzone

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0140602 - nucleolar peripheral inclusion body

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0004674 - protein serine/threonine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

References:

Genotypes:

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0001972 - abnormal cell separation after cytokinesis resulting in septated cell

References:

Genotypes:

FYPO:0000029 - abnormal chromosome segregation

References:

Genotypes:

FYPO:0005201 - abnormal mitotic cell cycle regulation during cellular response to heat stress

References:

Genotypes:

FYPO:0004292 - abnormal septum

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000417 - abolished cytokinesis

References:

Genotypes:

FYPO:0004936 - abolished DNA binding at PCB

References:

Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0002823 - abolished protein localization to mitotic spindle pole body during interphase

References:

Genotypes:

FYPO:0004753 - abolished protein localization to nucleus during mitotic interphase

References:

Genotypes:

FYPO:0000272 - abolished septum assembly

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0004044 - elongated tetranucleate vegetative cell

References:

Genotypes:

FYPO:0000344 - enlarged nucleus during vegetative growth

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002002 - multiseptate vegetative cell, septa grouped

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0006425 - normal meiotic sister chromatid cohesion at centromere during meiosis I

References:

Genotypes:

FYPO:0000411 - normal mitotic cell cycle

References:

Genotypes:

FYPO:0005207 - normal mitotic cell cycle regulation upon nitrogen source shift

References:

Genotypes:

FYPO:0000405 - normal mitotic G2/M phase transition

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0005216 - normal protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001903 - normal septation index

References:

Genotypes:

FYPO:0000673 - normal septum assembly

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0006824 - premature protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0007567 - premature protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

References:

Genotypes:

FYPO:0005633 - sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II

References:

Genotypes:

FYPO:0003245 - telophase nuclear clustering

References:

Genotypes:

FYPO:0002058 - viable cell population

References:

Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

References:

Genotypes:

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

References:

Genotypes:

FYPO:0001972 - abnormal cell separation after cytokinesis resulting in septated cell

References:

Genotypes:

FYPO:0000734 - abnormal meiotic spindle

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000710 - abnormal mitotic cell cycle arrest in response to nitrogen starvation

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000338 - abnormal mitotic spindle

References:

Genotypes:

FYPO:0007174 - abnormal protein localization to kinetochore during mitotic interphase

References:

Genotypes:

FYPO:0000676 - abnormal protein targeting to vacuole

References:

Genotypes:

FYPO:0005663 - abnormal re-entry into mitotic cell cycle after arrest in response to heat shock

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0004936 - abolished DNA binding at PCB

References:

Genotypes:

FYPO:0001683 - abolished mitotic spindle assembly

References:

Genotypes:

FYPO:0001734 - abolished mitotic spindle pole body separation

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0004763 - abolished protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0002555 - abolished protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0000941 - abolished protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0001424 - abolished protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0005366 - abolished protein phosphorylation during mitosis

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0000272 - abolished septum assembly

References:

Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0002026 - actomyosin contractile ring displaced from midpoint

References:

Genotypes:

FYPO:0002027 - angled actomyosin contractile ring

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001876 - decreased asymmetric protein localization, with protein localized to both mitotic spindle pole bodies during anaphase

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0003550 - decreased protein level during meiosis

References:

Genotypes:

FYPO:0004212 - decreased protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0006638 - decreased protein localization to medial cortex, with protein distributed in cell cortex, during vegetative growth

References:

Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0004935 - decreased RNA level during exit from mitosis

References:

Genotypes:

FYPO:0002636 - delayed onset of mitotic spindle elongation

References:

Genotypes:

FYPO:0003566 - delayed onset of mitotic spindle pole body separation

References:

Genotypes:

FYPO:0007257 - delayed onset of protein localization to meiotic spindle pole body during meiosis I

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0000344 - enlarged nucleus during vegetative growth

References:

Genotypes:

FYPO:0001677 - increased protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002970 - increased protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0004934 - increased RNA level during mitotic G1 phase

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0003682 - inviable after spore germination, without cell division, elongated multinucleate aseptate cell

References:

Genotypes:

FYPO:0003313 - inviable after spore germination, without cell division, mononucleate cell with elongated germ tube

References:

Genotypes:

FYPO:0002816 - inviable after spore germination, without cell division, multinucleate cell with elongated germ tube

References:

Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0004657 - inviable mononucleate multiseptate vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001369 - mislocalized actomyosin contractile ring

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0003210 - mislocalized, misoriented septum

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0000061 - multinucleate vegetative cell

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002002 - multiseptate vegetative cell, septa grouped

References:

Genotypes:

FYPO:0004367 - normal mitotic spindle assembly

References:

Genotypes:

FYPO:0000535 - normal mitotic spindle pole body localization

References:

Genotypes:

FYPO:0002799 - normal protein degradation

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0004083 - normal protein level

References:

Genotypes:

FYPO:0004328 - normal protein localization during mitosis

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0007451 - normal protein localization to cell cortex of cell tip during vegetative growth

References:

Genotypes:

FYPO:0001509 - normal protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0004764 - normal protein localization to meiotic spindle pole body during meiosis I

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0005709 - normal protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0004082 - normal protein phosphorylation during mitosis

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0007256 - premature protein localization to meiotic spindle pole body during prophase I

References:

Genotypes:

FYPO:0001984 - protein absent from cell during vegetative growth

References:

Genotypes:

FYPO:0000783 - protein mislocalized to cytoplasm during vegetative growth

References:

Genotypes:

FYPO:0003161 - RNA absent from cell during vegetative growth

References:

Genotypes:

FYPO:0001696 - sensitive to protein kinase inhibitor

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0004609 - spindle pole bodies present in increased numbers during meiosis

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002176 - viable vegetative cell with normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPFAM
PF00659POLO_boxPOLO_box_domPFAM
cd13118POLO_box_1POLO_box_1CDD
cd13117POLO_box_2POLO_box_2CDD
cd14099STKc_PLKCDD
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE_PATTERNS
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE_PATTERNS
PS50078POLO_BOXPOLO_box_domPROSITE_PROFILES
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE_PROFILES
SM00220serkin_6Prot_kinase_domSMART
G3DSA:3.30.200.20:FF:000042FUNFAM
G3DSA:3.30.1120.30:FF:000001FUNFAM
G3DSA:1.10.510.10:FF:001669FUNFAM
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
SSF82615Polo-box domainSUPERFAMILY
G3DSA:3.30.1120.30POLO box domainPOLO_box_dom_sfGENE3D
G3DSA:1.10.510.10Transferase(Phosphotransferase) domain 1GENE3D
PTHR24345SERINE/THREONINE-PROTEIN KINASE PLKPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:15062098 - Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.
Morrell JL et al. Curr Biol 2004 Apr 06;14(7):579-84
PMID:11676915 - S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.
Krapp A et al. Curr Biol 2001 Oct 16;11(20):1559-68
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.
Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46
PMID:33176152 - Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast.
Gallardo P et al. Cell Rep 2020 Nov 10;33(6):108377
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12615979 - Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase.
Reynolds N et al. J Cell Sci 2003 Apr 01;116(Pt 7):1377-87
PMID:11777938 - Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis.
May KM et al. J Cell Biol 2002 Jan 07;156(1):23-8
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
Goyal A et al. Genetics 2012 Apr;190(4):1235-50
PMID:22438582 - Spindle pole body components are reorganized during fission yeast meiosis.
Ohta M et al. Mol Biol Cell 2012 May;23(10):1799-811
PMID:22561704 - Regulation of cell cycle and stress responses under nitrosative stress in Schizosaccharomyces pombe.
Majumdar U et al. Free Radic Biol Med 2012 Jun 1;52(11-12):2186-200
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.
Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57
PMID:29196561 - Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I.
Miyazaki S et al. Cold Spring Harb Symp Quant Biol 2017;82:259-266
PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
PMID:40161431 - Characterization of temperature-sensitive alleles of anillin-like Mid1 and polo kinase Plo1 in Schizosaccharomyces pombe .
Park JS et al. MicroPubl Biol 2025;2025
PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.
Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119
PMID:12546793 - Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.
Krapp A et al. Curr Biol 2003 Jan 21;13(2):168-72
PMID:24920823 - Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.
Rachfall N et al. Mol Biol Cell 2014 Aug 01;25(15):2250-9
PMID:12479804 - Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).
Guertin DA et al. Dev Cell 2002 Dec;3(6):779-90
PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:10436027 - Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe.
Mulvihill DP et al. Mol Biol Cell 1999 Aug;10(8):2771-85
PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.
Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72
PMID:12186944 - Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.
Mulvihill DP et al. J Cell Sci 2002 Sep 15;115(Pt 18):3575-86
PMID:18303049 - Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.
Dischinger S et al. J Cell Sci 2008 Mar 15;121(Pt 6):843-53
PMID:15537703 - The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.
Karagiannis J et al. Mol Biol Cell 2005 Jan;16(1):358-71
PMID:19075108 - Assembly of normal actomyosin rings in the absence of Mid1p and cortical nodes in fission yeast.
Huang Y et al. J Cell Biol 2008 Dec 15;183(6):979-88
PMID:22451489 - Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.
Szilagyi Z et al. Mol Cell Biol 2012 Jun;32(11):2099-109
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25356547 - A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe.
Bhutta MS et al. PLoS One 2014;9(10):e111789
PMID:25487150 - A PP1-PP2A phosphatase relay controls mitotic progression.
Grallert A et al. Nature 2015 Jan 01;517(7532):94-98
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:22809626 - Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast.
Wang Y et al. Mol Biol Cell 2012 Sep;23(17):3348-56
PMID:24424027 - Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells.
Atkin J et al. J Cell Sci 2014 Mar 15;127(Pt 6):1346-56
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.
Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928
PMID:21098641 - Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p.
Papadopoulou K et al. J Cell Sci 2010 Dec 15;123(Pt 24):4374-81
PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
Jourdain I et al. PLoS One 2013;8(1):e54142
PMID:21965528 - Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.
Hálová L et al. J Cell Sci 2011 Oct 15;124(Pt 20):3441-9
PMID:23986474 - Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
Tay YD et al. J Cell Sci 2013 Nov 01;126(Pt 21):5052-61
PMID:15857958 - Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Bimbó A et al. Mol Biol Cell 2005 Jul;16(7):3162-75
PMID:27618268 - Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2.
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