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protein coding gene - plo1 (SPAC23C11.16) - Polo kinase Plo1

Gene summary

Standard name
plo1
Systematic ID
SPAC23C11.16
Product
Polo kinase Plo1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P50528
ORFeome ID
27/27F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2164231..2166765 forward strand

Annotation

Comment

PBO:0001387 - function depends on a functional spindle assembly checkpoint

References:

PBO:0001386 - function depends on recruitment to the spindle pole body

References:

PBO:0024819 - promoter contains PCB

References:

PBO:0001385 - stress response pathway signalling (SRP), mediated phosphorylation of Ser402 ensures efficient reinitiation of tip growth and cell division during recovery from particular stress

References:

PBO:0001384 - stress response pathway signalling (SRP), mediated phosphorylation of Ser402 regulates the timing of commitment to mitosis

References:

GO biological process

GO:0051523 - cell growth mode switching, monopolar to bipolar

References:

GO:0031619 - homologous chromosome orientation in meiotic metaphase I

References:

GO:0045143 - homologous chromosome segregation

References:

GO:0035556 - intracellular signal transduction

References:

GO:1990571 - meiotic centromere clustering

References:

GO:1990813 - meiotic centromeric cohesion protection in anaphase I

References:

GO:1990395 - meiotic spindle pole body organization

References:

GO:0007052 - mitotic spindle organization

References:

GO:0140480 - mitotic spindle pole body insertion into the nuclear envelope

References:

GO:0045793 - positive regulation of cell size

References:

GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

References:

GO:1903501 - positive regulation of mitotic actomyosin contractile ring assembly

References:

GO:1903490 - positive regulation of mitotic cytokinesis

References:

GO:0045842 - positive regulation of mitotic metaphase/anaphase transition

References:

GO:0140429 - positive regulation of mitotic sister chromatid biorientation

References:

GO:0046827 - positive regulation of protein export from nucleus

References:

GO:0031031 - positive regulation of septation initiation signaling

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0051455 - spindle attachment to meiosis I kinetochore

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0061496 - half bridge of mitotic spindle pole body

References:

GO:0061497 - inner plaque of mitotic spindle pole body

References:

GO:0000776 - kinetochore

References:

GO:0072687 - meiotic spindle

References:

GO:0090619 - meiotic spindle pole

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0072686 - mitotic spindle

References:

GO:1990023 - mitotic spindle midzone

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0140602 - nucleolar peripheral inclusion body

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0004672 - protein kinase activity

References:

GO:0004674 - protein serine/threonine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

References:

Genotypes:

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0001972 - abnormal cell separation after cytokinesis resulting in septated cell

References:

Genotypes:

FYPO:0000029 - abnormal chromosome segregation

References:

Genotypes:

FYPO:0005201 - abnormal mitotic cell cycle regulation during cellular response to heat stress

References:

Genotypes:

FYPO:0000147 - abnormal NETO

References:

Genotypes:

FYPO:0004292 - abnormal septum

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000417 - abolished cytokinesis

References:

Genotypes:

FYPO:0004936 - abolished DNA binding at PCB

References:

Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0002823 - abolished protein localization to mitotic spindle pole body during interphase

References:

Genotypes:

FYPO:0004753 - abolished protein localization to nucleus during mitotic interphase

References:

Genotypes:

FYPO:0000272 - abolished septum assembly

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0004044 - elongated tetranucleate vegetative cell

References:

Genotypes:

FYPO:0000344 - enlarged nucleus during vegetative growth

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002002 - multiseptate vegetative cell, septa grouped

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0006425 - normal meiotic sister chromatid cohesion at centromere during meiosis I

References:

Genotypes:

FYPO:0000411 - normal mitotic cell cycle

References:

Genotypes:

FYPO:0005207 - normal mitotic cell cycle regulation upon nitrogen source shift

References:

Genotypes:

FYPO:0000405 - normal mitotic G2/M phase transition

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0005216 - normal protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001903 - normal septation index

References:

Genotypes:

FYPO:0000673 - normal septum assembly

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0006824 - premature protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0007567 - premature protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

References:

Genotypes:

FYPO:0005633 - sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II

References:

Genotypes:

FYPO:0003245 - telophase nuclear clustering

References:

Genotypes:

FYPO:0002058 - viable cell population

References:

Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

References:

Genotypes:

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

References:

Genotypes:

FYPO:0001972 - abnormal cell separation after cytokinesis resulting in septated cell

References:

Genotypes:

FYPO:0000734 - abnormal meiotic spindle

References:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000710 - abnormal mitotic cell cycle arrest in response to nitrogen starvation

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000338 - abnormal mitotic spindle

References:

Genotypes:

FYPO:0006387 - abnormal mitotic spindle pole body organization

References:

Genotypes:

FYPO:0000147 - abnormal NETO

References:

Genotypes:

FYPO:0007174 - abnormal protein localization to kinetochore during mitotic interphase

References:

Genotypes:

FYPO:0000939 - abnormal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000676 - abnormal protein targeting to vacuole

References:

Genotypes:

FYPO:0005663 - abnormal re-entry into mitotic cell cycle after arrest in response to heat shock

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0004936 - abolished DNA binding at PCB

References:

Genotypes:

FYPO:0001683 - abolished mitotic spindle assembly

References:

Genotypes:

FYPO:0001734 - abolished mitotic spindle pole body separation

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0004763 - abolished protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0002555 - abolished protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0000941 - abolished protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0001424 - abolished protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0005366 - abolished protein phosphorylation during mitosis

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0000272 - abolished septum assembly

References:

Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0002026 - actomyosin contractile ring displaced from midpoint

References:

Genotypes:

FYPO:0002027 - angled actomyosin contractile ring

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001876 - decreased asymmetric protein localization, with protein localized to both mitotic spindle pole bodies during anaphase

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0003550 - decreased protein level during meiosis

References:

Genotypes:

FYPO:0004212 - decreased protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0006638 - decreased protein localization to medial cortex, with protein distributed in cell cortex, during vegetative growth

References:

Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0004935 - decreased RNA level during exit from mitosis

References:

Genotypes:

FYPO:0010113 - delayed onset of histone H3-S10 phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002636 - delayed onset of mitotic spindle elongation

References:

Genotypes:

FYPO:0003566 - delayed onset of mitotic spindle pole body separation

References:

Genotypes:

FYPO:0007257 - delayed onset of protein localization to meiotic spindle pole body during meiosis I

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0000344 - enlarged nucleus during vegetative growth

References:

Genotypes:

FYPO:0001677 - increased protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002970 - increased protein localization to mitotic spindle pole body during metaphase

References:

Genotypes:

FYPO:0004934 - increased RNA level during mitotic G1 phase

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0003682 - inviable after spore germination, without cell division, elongated multinucleate aseptate cell

References:

Genotypes:

FYPO:0003313 - inviable after spore germination, without cell division, mononucleate cell with elongated germ tube

References:

Genotypes:

FYPO:0002816 - inviable after spore germination, without cell division, multinucleate cell with elongated germ tube

References:

Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0004657 - inviable mononucleate multiseptate vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001369 - mislocalized actomyosin contractile ring

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0003210 - mislocalized, misoriented septum

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0000061 - multinucleate vegetative cell

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002002 - multiseptate vegetative cell, septa grouped

References:

Genotypes:

FYPO:0004367 - normal mitotic spindle assembly

References:

Genotypes:

FYPO:0000535 - normal mitotic spindle pole body localization

References:

Genotypes:

FYPO:0002799 - normal protein degradation

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0004083 - normal protein level

References:

Genotypes:

FYPO:0004328 - normal protein localization during mitosis

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0007451 - normal protein localization to cell cortex of cell tip during vegetative growth

References:

Genotypes:

FYPO:0001509 - normal protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0004764 - normal protein localization to meiotic spindle pole body during meiosis I

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0005709 - normal protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0004082 - normal protein phosphorylation during mitosis

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0002516 - premature mitotic G2/M phase transition

References:

Genotypes:

FYPO:0007256 - premature protein localization to meiotic spindle pole body during prophase I

References:

Genotypes:

FYPO:0001984 - protein absent from cell during vegetative growth

References:

Genotypes:

FYPO:0000783 - protein mislocalized to cytoplasm during vegetative growth

References:

Genotypes:

FYPO:0003161 - RNA absent from cell during vegetative growth

References:

Genotypes:

FYPO:0001696 - sensitive to protein kinase inhibitor

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0004609 - spindle pole bodies present in increased numbers during meiosis

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002176 - viable vegetative cell with normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPfam
PF00659POLO_boxPOLO_box_domPfam
cd13117POLO_box_2POLO_box_2CDD
cd13118POLO_box_1POLO_box_1CDD
cd14099STKc_PLKCDD
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE patterns
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE patterns
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE profiles
PS50078POLO_BOXPOLO_box_domPROSITE profiles
SM00220S_TKcProt_kinase_domSMART
G3DSA:1.10.510.10:FF:001669CATH-FunFam
G3DSA:3.30.1120.30:FF:000001CATH-FunFam
G3DSA:1.10.510.10CATH-Gene3D
G3DSA:3.30.1120.30POLO_box_dom_sfCATH-Gene3D
SSF56112Kinase-like_dom_sfSUPERFAMILY
SSF82615SUPERFAMILY
PTHR24345PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:24424027 - Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells.
Atkin J et al. J Cell Sci 2014 Mar 15;127(Pt 6):1346-56
PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
PMID:21965528 - Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.
Hálová L et al. J Cell Sci 2011 Oct 15;124(Pt 20):3441-9
PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.
Hanna SM et al. G3 (Bethesda) 2024 Oct 29;
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:23222840 - Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast.
Grallert A et al. Nat Cell Biol 2013 Jan;15(1):88-95
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23966468 - Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.
Zhu YH et al. Mol Biol Cell 2013 Oct;24(20):3187-204
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:15857958 - Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Bimbó A et al. Mol Biol Cell 2005 Jul;16(7):3162-75
PMID:10930468 - Analysis of mid1p, a protein required for placement of the cell division site, reveals a link between the nucleus and the cell surface in fission yeast.
Paoletti A et al. Mol Biol Cell 2000 Aug;11(8):2757-73
PMID:12479804 - Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).
Guertin DA et al. Dev Cell 2002 Dec;3(6):779-90
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12411492 - Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.
Anderson M et al. EMBO J 2002 Nov 01;21(21):5745-55
PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6
PMID:31591131 - F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe .
Hercyk BS et al. Genetics 2019 Dec;213(4):1341-1356
PMID:15572668 - C-terminal anchoring of mid1p to membranes stabilizes cytokinetic ring position in early mitosis in fission yeast.
Celton-Morizur S et al. Mol Cell Biol 2004 Dec;24(24):10621-35
PMID:23333317 - Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
Grallert A et al. Curr Biol 2013 Feb 04;23(3):213-22
PMID:7744248 - The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.
Ohkura H et al. Genes Dev 1995 May 01;9(9):1059-73
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:11250892 - The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe.
Tanaka K et al. EMBO J 2001 Mar 15;20(6):1259-70
PMID:22561704 - Regulation of cell cycle and stress responses under nitrosative stress in Schizosaccharomyces pombe.
Majumdar U et al. Free Radic Biol Med 2012 Jun 1;52(11-12):2186-200
PMID:12815070 - Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe.
MacIver FH et al. Genes Dev 2003 Jun 15;17(12):1507-23
PMID:27618268 - Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2.
Mora-Santos MD et al. Curr Biol 2016 Oct 10;26(19):2642-2650
PMID:34674264 - Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.
Chen JS et al. FEBS Lett 2021 Nov;595(22):2781-2792
PMID:38448160 - Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I.
Liu Y et al. Life Sci Alliance 2024 May;7(5)
PMID:15062098 - Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.
Morrell JL et al. Curr Biol 2004 Apr 06;14(7):579-84
PMID:18378776 - The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.
Clifford DM et al. J Cell Biol 2008 Apr 07;181(1):79-88
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:32084401 - The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.
Basu S et al. Curr Biol 2020 Mar 09;30(5):883-892.e4
PMID:40161431 - Characterization of temperature-sensitive alleles of anillin-like Mid1 and polo kinase Plo1 in Schizosaccharomyces pombe .
Park JS et al. MicroPubl Biol 2025;2025
PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.
Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93
PMID:15917811 - Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast.
Petersen J et al. Nature 2005 May 26;435(7041):507-12
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:18057023 - Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors.
Papadopoulou K et al. J Cell Sci 2008 Jan 01;121(Pt 1):38-47
PMID:15195092 - Periodic gene expression program of the fission yeast cell cycle.
Rustici G et al. Nat Genet 2004 Aug;36(8):809-17
PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.
Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51
PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
Goyal A et al. Genetics 2012 Apr;190(4):1235-50
PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
Jourdain I et al. PLoS One 2013;8(1):e54142
PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.
Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928
PMID:34133218 - Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Bestul AJ et al. Mol Biol Cell 2021 Aug 01;32(16):1487-1500
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
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