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protein coding gene - hhp2 (SPAC23C4.12) - serine/threonine protein kinase (CK1 family) Hhp2

Gene summary

Standard name
hhp2
Systematic ID
SPAC23C4.12
Product
serine/threonine protein kinase (CK1 family) Hhp2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P40236
ORFeome ID
23/23D12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1048998..1051136 forward strand

Annotation

Complementation

PBO:0024474 - functionally complements S. cerevisiae HRR25

References:

Disease association

MONDO:0014088 - advanced sleep phase syndrome 2

References:

GO biological process

GO:0051755 - meiotic sister chromatid arm separation

References:

GO:0010895 - negative regulation of ergosterol biosynthetic process

References:

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO:2000781 - positive regulation of double-strand break repair

References:

GO:0045807 - positive regulation of endocytosis

References:

GO:0006282 - regulation of DNA repair

References:

GO:0090006 - regulation of linear element assembly

References:

GO:0032933 - SREBP signaling pathway

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0005737 - cytoplasm

References:

GO:0035838 - growing cell tip

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0000228 - nuclear chromosome

References:

GO:0005634 - nucleus

References:

GO:0005816 - spindle pole body

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0005515 - protein binding

References:

GO:0004674 - protein serine/threonine kinase activity

References:

GO:0004713 - protein tyrosine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0004585 - abnormal linear element morphology

References:

Genotypes:

FYPO:0003564 - abnormal meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0002957 - abnormal protein localization to nucleus during meiosis

References:

Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0004939 - abolished protein phosphorylation during meiotic cell cycle

References:

Genotypes:

FYPO:0000912 - abolished protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0005781 - decreased duration of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0005577 - decreased protein phosphorylation during meiotic cell cycle

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000778 - delayed onset of double-strand break repair

References:

Genotypes:

FYPO:0006531 - delayed onset of protein degradation during meiosis

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0003970 - incomplete mitotic sister chromatid segregation, with chromatin bridge

References:

Genotypes:

FYPO:0004709 - increased number of Rad52 foci

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0005986 - linear elements present in decreased numbers

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0002219 - normal chromosome disjunction at meiosis I

References:

Genotypes:

FYPO:0001033 - normal double-strand break repair

References:

Genotypes:

FYPO:0004667 - normal meiotic sister chromatid cohesion at centromere

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0002635 - normal protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000094 - sensitive to benomyl

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

References:

Genotypes:

FYPO:0001495 - viable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

Protein features

PBO:0111811 - casein kinase I subfamily

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000357 - abnormal shmoo morphology

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0006530 - abolished protein localization to centromere during meiotic prophase II

References:

Genotypes:

FYPO:0000912 - abolished protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0000846 - decreased protein degradation during vegetative growth

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0001274 - decreased protein level during cellular response to hypoxia

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0003251 - decreased transcription from SRE promoter

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0002318 - increased cellular ergosterol level

References:

Genotypes:

FYPO:0002700 - increased protein kinase activity

References:

Genotypes:

FYPO:0000836 - increased protein level

References:

Genotypes:

FYPO:0001256 - increased protein level during cellular response to hypoxia

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0007297 - increased transcription from SRE promoter

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0002004 - microtubules absent from cell

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001033 - normal double-strand break repair

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0001686 - normal growth on carbendazim

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0000964 - normal growth on thiabendazole

References:

Genotypes:

FYPO:0005578 - normal intergenic meiotic recombination

References:

Genotypes:

FYPO:0003702 - normal microtubule cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0001513 - normal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001380 - normal nuclear morphology during vegetative growth

References:

Genotypes:

FYPO:0003790 - normal protein localization during meiosis

References:

Genotypes:

FYPO:0006532 - normal protein localization to centromere during meiotic prophase II

References:

Genotypes:

FYPO:0003316 - normal protein localization to growing cell tip

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002635 - normal protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0000094 - sensitive to benomyl

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0002167 - sensitive to ethyl methanesulfonate

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

FYPO:0002176 - viable vegetative cell with normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPFAM
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE_PATTERNS
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE_PATTERNS
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE_PROFILES
SM00220serkin_6Prot_kinase_domSMART
G3DSA:1.10.510.10:FF:000635FUNFAM
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:1.10.510.10Transferase(Phosphotransferase) domain 1GENE3D
PTHR11909CASEIN KINASE-RELATEDCK1_Ser-Thr_kinasePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29742018 - The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole.
Elmore ZC et al. Mol Biol Cell 2018 Jul 01;29(13):1664-1674
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:8026462 - Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair.
Dhillon N et al. EMBO J 1994 Jun 15;13(12):2777-88
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:24327658 - Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.
Brookheart RT et al. J Biol Chem 2014 Jan 31;289(5):2725-35
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.
Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119
PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.
Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.
Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24
PMID:39387272 - The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex.
Cullati SN et al. Mol Cell Biol 2024 Oct 10;:1-15
PMID:7803855 - Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity.
Hoekstra MF et al. Mol Biol Cell 1994 Aug;5(8):877-86
PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.
Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.
Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16990132 - Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
Petronczki M et al. Cell 2006 Sep 22;126(6):1049-64
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.
Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225
PMID:20581463 - Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.
Rumpf C et al. Cell Cycle 2010 Jul 01;9(13):2657-62
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26982200 - HIV-1 Protease in the Fission Yeast Schizosaccharomyces pombe.
Benko Z et al. PLoS One 2016;11(3):e0151286
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:32053662 - AMPKα Subunit Ssp2 and Glycogen Synthase Kinases Gsk3/Gsk31 are involved in regulation of sterol regulatory element-binding protein (SREBP) activity in fission yeast.
Miao H et al. PLoS One 2020;15(2):e0228845
PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6
PMID:28774892 - Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.
Chan KY et al. J Cell Biol 2017 Sep 04;216(9):2795-2812
GO_REF:0000002 - Comments
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:34402513 - Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.
Willet AH et al. J Cell Sci 2021 Aug 15;134(16)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:41354344 - The mitotic functions of a fission yeast CK1 enzyme are regulated by Cdk1-dependent and auto-phosphorylation.
Akizuki K et al. J Biol Chem 2025 Dec 05;:111007