PomBase home

protein coding gene - atg15 (SPAC23C4.16c) - autophagy associated lysophospholipase Atg15

Gene summary

Standard name
atg15
Systematic ID
SPAC23C4.16c
Product
autophagy associated lysophospholipase Atg15
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13934
ORFeome ID
20/20D06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1055849..1057559 reverse strand

Annotation

Disease association

MONDO:0008206 - benign paroxysmal tonic upgaze of childhood with ataxia

References:

GO biological process

GO:0016236 - macroautophagy

References:

GO:0034496 - multivesicular body membrane disassembly

References:

GO:0046461 - neutral lipid catabolic process

References:

GO:0006660 - phosphatidylserine catabolic process

References:

GO:0034727 - piecemeal microautophagy of the nucleus

References:

GO cellular component

GO:0000328 - fungal-type vacuole lumen

References:

GO:0032585 - multivesicular body membrane

References:

GO molecular function

GO:0004622 - phosphatidylcholine lysophospholipase A1 activity

References:

GO:0004806 - triacylglycerol lipase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004670 - abnormal macroautophagy during nitrogen starvation

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000380 - abolished macroautophagy

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01764Lipase_3Fungal_lipase-typePFAM
cd00519Lipase_3CDD
G3DSA:3.40.50.1820:FF:000129FUNFAM
SSF53474alpha/beta-HydrolasesAB_hydrolase_foldSUPERFAMILY
G3DSA:3.40.50.1820alpha/beta hydrolaseAB_hydrolase_foldGENE3D
PTHR47175LIPASE ATG15-RELATEDATG15_LipasePANTHER

Orthologs

References / Literature

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000044 - Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
Pfam:PF01764 - Unknown title
PMID:19778961 - Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.
Mukaiyama H et al. Microbiology (Reading) 2009 Dec;155(Pt 12):3816-3826
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8