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protein coding gene - aah2 (SPAC23D3.14c) - glycosyl hydrolase family 13, implicated in cell wall biogenesis Aah2

Gene summary

Standard name
aah2
Systematic ID
SPAC23D3.14c
Product
glycosyl hydrolase family 13, implicated in cell wall biogenesis Aah2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09840
ORFeome ID
37/37A12
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome I: 4373039..4374987 reverse strand

Annotation

GO cellular component

GO:0009897 - external side of plasma membrane

References:

GO molecular function

GO:0004134 - 4-alpha-glucanotransferase activity

References:

Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

References:

Multi-locus phenotype

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00128Alpha-amylaseGH13_cat_domPFAM
cd11319AmyAc_euk_AmyACDD
SM00642aamyGH13_cat_domSMART
G3DSA:2.60.40.1180:FF:000037FUNFAM
G3DSA:3.20.20.80:FF:000120FUNFAM
SSF51011Glycosyl hydrolase domainSUPERFAMILY
SSF51445(Trans)glycosidasesGH_hydrolase_sfSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:2.60.40.1180Glyco_hydro_bGENE3D
PTHR10357ALPHA-AMYLASE FAMILY MEMBERPANTHER
PIRSF001024Alph-amyl_fungA-amylase-likePIRSF

Orthologs

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.
Bednor L et al. mBio 2023 Dec 22;:e0306223
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping
PMID:16751704 - An alpha-amylase homologue, aah3, encodes a GPI-anchored membrane protein required for cell wall integrity and morphogenesis in Schizosaccharomyces pombe.
Morita T et al. Biosci Biotechnol Biochem 2006 Jun;70(6):1454-63
PMID:40668835 - α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.
Jacob A et al. Proc Natl Acad Sci U S A 2025 Jul 22;122(29):e2505509122
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531