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protein coding gene - lam4 (SPAC23D3.16) - Ragulator complex subunit, human LAMTOR4 ortholog

Gene summary

Standard name
lam4
Systematic ID
SPAC23D3.16
Product
Ragulator complex subunit, human LAMTOR4 ortholog
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
C6Y4A8
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4365647..4366456 forward strand

Annotation

GO biological process

GO:1903432 - regulation of TORC1 signaling

References:

GO cellular component

GO:0000329 - fungal-type vacuole membrane

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GO:0071986 - Ragulator complex

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Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004249 - abnormal protein localization to vacuolar membrane

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Genotypes:

FYPO:0004250 - abolished protein localization to vacuolar membrane

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0001522 - normal growth on caffeine

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Genotypes:

FYPO:0002672 - normal growth on rapamycin

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Genotypes:

FYPO:0004248 - normal protein localization to vacuolar membrane

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Genotypes:

FYPO:0001029 - resistance to canavanine

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

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PBO:0011071 - conserved in eukaryotes only

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PBO:0011064 - conserved in fungi

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PBO:0011069 - conserved in metazoa

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PBO:0011070 - conserved in vertebrates

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PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

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PBO:0000082 - new gene

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Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.
Chia KH et al. Elife 2017 Dec 04;6
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105