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protein coding gene - sms1 (SPAC23E2.03c) - pheromone-MAPK scaffold Sms1

Gene summary

Standard name
sms1
Systematic ID
SPAC23E2.03c
Product
pheromone-MAPK scaffold Sms1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ste7
UniProt ID
Q10136
ORFeome ID
46/46C06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 450860..453561 reverse strand

Annotation

GO biological process

GO:0071507 - pheromone response MAPK cascade

References:

GO:0031139 - positive regulation of conjugation with cellular fusion

References:

GO:0062038 - positive regulation of pheromone response MAPK cascade

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GO cellular component

GO:0090726 - cortical dynamic polarity patch

References:

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0043332 - mating projection tip

References:

GO:0070867 - mating projection tip membrane

References:

GO:0005634 - nucleus

References:

GO:0005886 - plasma membrane

References:

GO molecular function

GO:0005078 - MAP kinase scaffold activity

References:

GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000569 - abolished shmoo formation

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001886 - meiotic cell cycle entry and sporulation in haploid

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Genotypes:

FYPO:0004422 - normal protein phosphorylation

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Genotypes:

Protein features

PBO:0111766 - arrestin family

Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000021 - protein present

References:

PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006669 - abnormal mating between three cells

References:

Genotypes:

FYPO:0005989 - abnormal protein localization during mating

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Genotypes:

FYPO:0004838 - abnormal protein localization to plasma membrane

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Genotypes:

FYPO:0000302 - abnormal response to pheromone

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Genotypes:

FYPO:0002678 - abolished protein phosphorylation

References:

Genotypes:

FYPO:0008412 - abolished protein phosphorylation during mating

References:

Genotypes:

FYPO:0000569 - abolished shmoo formation

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0000822 - decreased concentration of P-factor in growth medium

References:

Genotypes:

FYPO:0000303 - decreased conjugation frequency

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Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0003770 - decreased transcriptional response to pheromone

References:

Genotypes:

FYPO:0001867 - increased shmoo formation

References:

Genotypes:

FYPO:0003031 - mating without nitrogen starvation

References:

Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Protein features

IDNameInterPro nameDB name
G3DSA:2.60.40.640Arrestin-like_C_sfGENE3D
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Proline-richdisorder_predictionMOBIDB-Proline-rich

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.
Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.
Sieber B et al. Nat Commun 2026 Mar 17;
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.
Aono T et al. Yeast 1994 Jun;10(6):757-70
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:10835379 - Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis.
Matsuyama A et al. Genetics 2000 Jun;155(2):539-49
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.
Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008