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protein coding gene - sib1 (SPAC23G3.02c) - ferrichrome synthetase Sib1

Gene summary

Standard name
sib1
Systematic ID
SPAC23G3.02c
Product
ferrichrome synthetase Sib1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7T1
ORFeome ID
50/50A04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 854453..869684 reverse strand

Annotation

GO biological process

GO:0010106 - cellular response to iron ion starvation

References:

GO:0031169 - ferrichrome biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0016881 - acid-amino acid ligase activity

References:

GO:1904091 - non-ribosomal peptide synthetase activity

References:

GO:0031177 - phosphopantetheine binding

References:

Genome organisation

PBO:0091284 - co-transcribed with divergently oriented functionally related gene

References:

PBO:0091283 - divergently oriented to functionally related gene

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:00159 - O-phosphopantetheine-L-serine

References:

Multi-locus phenotype

FYPO:0001723 - ferrichrome absent from cell

References:

Genotypes:

FYPO:0001814 - normal cell population growth during iron starvation

References:

Genotypes:

FYPO:0002015 - sensitive to iron ion starvation

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0001723 - ferrichrome absent from cell

References:

Genotypes:

FYPO:0009101 - increased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0004295 - multiseptate cell

References:

Genotypes:

FYPO:0001814 - normal cell population growth during iron starvation

References:

Genotypes:

FYPO:0001691 - normal growth on paraquat

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0002988 - sensitive to ammonium

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00501AMP-bindingAMP-dep_synth/lig_domPfam
PF00550PP-bindingPP-bd_ACPPfam
PF00668CondensationCondensation_domPfam
PF23297ACP_SdgA_CPP-bd_ACPPfam
cd05918A_NRPS_SidN3_likeCDD
cd19542CT_NRPS-likeCDD
PS00012PHOSPHOPANTETHEINEPpantetheine_attach_sitePROSITE patterns
PS00455AMP_BINDINGAMP-binding_CSPROSITE patterns
PS50075CARRIERPP-bd_ACPPROSITE profiles
SM00823PKS_PPPKS_PP-bdSMART
SM01294PKS_PP_betabranchSMART
G3DSA:1.10.1200.10:FF:000118CATH-FunFam
G3DSA:3.30.300.30:FF:000033CATH-FunFam
G3DSA:3.30.559.30:FF:000030CATH-FunFam
G3DSA:3.30.559.30:FF:000035CATH-FunFam
G3DSA:3.30.559.30:FF:000100CATH-FunFam
G3DSA:3.30.559.30:FF:000101CATH-FunFam
G3DSA:3.40.50.12780:FF:000024CATH-FunFam
G3DSA:1.10.1200.10ACP-like_sfCATH-Gene3D
G3DSA:3.30.300.30AMP-b_sfCATH-Gene3D
G3DSA:3.30.559.10CAT-like_dom_sfCATH-Gene3D
G3DSA:3.30.559.30CATH-Gene3D
G3DSA:3.40.50.12780ANL_N_sfCATH-Gene3D
SSF47336ACP-like_sfSUPERFAMILY
SSF52777SUPERFAMILY
SSF56801SUPERFAMILY
PTHR45527PANTHER
TIGR01733AA-adenyl-domAA_adenyl_domNCBIFAM
CoilCOILS

Orthologs

References / Literature

PMID:36302945 - Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast.
Chiu PC et al. Sci Rep 2022 Oct 27;12(1):17411
PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
Bednor L et al. RNA 2026 Apr 13;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:15689108 - Ferrichrome in Schizosaccharomyces pombe--an iron transport and iron storage compound.
Schrettl M et al. Biometals 2004 Dec;17(6):647-54
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24385927 - The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.
Mbogning J et al. PLoS Genet 2013;9(12):e1004029
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.
Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16502473 - Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungi.
Schwecke T et al. Chembiochem 2006 Apr;7(4):612-22
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Rustici G et al. Genome Biol 2007;8(5):R73
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000051 - S. pombe keyword mapping
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.
Garg A et al. RNA 2021 Feb 12;27(5):560-70
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:20435771 - Iron-dependent remodeling of fungal metabolic pathways associated with ferrichrome biosynthesis.
Mercier A et al. Appl Environ Microbiol 2010 Jun;76(12):3806-17
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.
Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;