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protein coding gene - mrp2 (SPAC23H3.07c) - mitochondrial ribosomal protein subunit S14

Gene summary

Standard name
mrp2
Systematic ID
SPAC23H3.07c
Product
mitochondrial ribosomal protein subunit S14
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O42859
ORFeome ID
03/03B08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2504733..2505884 reverse strand

Annotation

Disease association

MONDO:0032712 - combined oxidative phosphorylation deficiency 38

References:

MONDO:0014815 - intellectual disability, autosomal recessive 52

References:

GO biological process

GO:0032543 - mitochondrial translation

References:

GO cellular component

GO:0005763 - mitochondrial small ribosomal subunit

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0003735 - structural constituent of ribosome

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00253Ribosomal_S14Ribosomal_uS14Pfam
G3DSA:1.10.287.1480:FF:000001CATH-FunFam
G3DSA:1.10.287.1480CATH-Gene3D
SSF57716SUPERFAMILY
PTHR19836Ribosomal_uS14PANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31