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protein coding gene - erv25 (SPAC23H4.03c) - COPII p24 cargo receptor complex subunit Erv25

Gene summary

Standard name
erv25
Systematic ID
SPAC23H4.03c
Product
COPII p24 cargo receptor complex subunit Erv25
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13946
ORFeome ID
09/09G08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1604002..1605116 forward strand

Annotation

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0007030 - Golgi organization

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0030134 - COPII-coated ER to Golgi transport vesicle

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

References:

GO:0005794 - Golgi apparatus

References:

GO molecular function

GO:0038024 - cargo receptor activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01105EMP24_GP25LGOLD_domPFAM
SM01190EMP24_GP25L_2GOLD_domSMART
PTHR22811TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEINEmp24-likePANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:41556658 - p24 family proteins are critical for cell wall integrity, protein secretion, and virulence in Candida albicans .
Yu X et al. mSphere 2026 Feb 24;11(2):e0082725
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623