protein coding gene - slm3 (SPAC23H4.04) - mitochondrial tRNA-specific 2-thiouridylase Slm3

Gene summary

Standard name: slm3
Systematic ID: SPAC23H4.04
Product: mitochondrial tRNA-specific 2-thiouridylase Slm3
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O13947
ORFeome ID: 21/21D02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 1601412..1602960 reverse strand

Annotation

Disease association

MONDO:0013111 - acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins

References:

PB_REF:0000006

MONDO:0010799 - deafness, aminoglycoside-induced

References:

PB_REF:0000006

MONDO:0005027 - epilepsy

References:

PB_REF:0000003

GO biological process

GO:1990799 - mitochondrial tRNA wobble position uridine thiolation

References:

GO_REF:0000033

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0103016 - tRNA-uridine 2-sulfurtransferase activity

References:

GO_REF:0000033

Modification

MOD:00689 - disulfide crosslinked residues

References:

PMID:36408920

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

slm3delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

slm3delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF20259	tRNA_Me_trans_M	MnmA-like_central	PFAM
PF20258	tRNA_Me_trans_C	MnmA-like_C	PFAM
PF03054	tRNA_Me_trans		PFAM
cd01998	MnmA_TRMU-like	MnmA-like	CDD
SSF52402	Adenine nucleotide alpha hydrolases-like		SUPERFAMILY
G3DSA:3.40.50.620	HUPs	Rossmann-like_a/b/a_fold	GENE3D
G3DSA:2.40.30.10	Translation factors		GENE3D
G3DSA:2.30.30.280		MnmA-like_central_sf	GENE3D
PTHR11933	TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE		PANTHER
TIGR00420	trmU	MnmA-like	NCBIFAM
NF001138	PRK00143.1		NCBIFAM

Orthologs

TRMU (HGNC:25481) Homo sapiens
slm3 (SJAG_00358) Schizosaccharomyces japonicus
SLM3 (YDL033C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83