protein coding gene - alp13 (SPAC23H4.12) - Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3

Gene summary

Standard name

alp13

Systematic ID

SPAC23H4.12

Product

Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

eaf3

UniProt ID

O13953

ORFeome ID

16/16C09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1587022..1588577 reverse strand

Annotation

Protein features

Orthologs

• MORF4 (HGNC:15773) Homo sapiens
• MORF4L2 (HGNC:16849) Homo sapiens
• MORF4L1 (HGNC:16989) Homo sapiens
• alp13 (SJAG_00349) Schizosaccharomyces japonicus
• EAF3 (YPR023C) Saccharomyces cerevisiae

References / Literature

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:39878217 - The ortholog of human DNAJC9 promotes histone H3-H4 degradation and is counteracted by Asf1 in fission yeast.

Ding Y et al. Nucleic Acids Res 2025 Jan 24;53(3)

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:22990236 - Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.

Shim YS et al. EMBO J 2012 Nov 28;31(23):4375-87

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:18252195 - Methylations of histone H3 lysine 9 and lysine 36 are functionally linked to DNA replication checkpoint control in fission yeast.

Kim HS et al. Biochem Biophys Res Commun 2008 Apr 04;368(2):419-25

PMID:19040720 - Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Shevchenko A et al. Genome Biol 2008;9(11):R167

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:27268234 - Both H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast.

Yang H et al. Biochem Biophys Res Commun 2016 Aug 05;476(4):515-521

PMID:23032292 - Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription.

Hennig BP et al. EMBO Rep 2012 Nov 06;13(11):997-1003

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:33468217 - Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.

Weigt M et al. Epigenetics Chromatin 2021 Jan 19;14(1):8

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)

PMID:37076472 - Two assembly modes for SIN3 histone deacetylase complexes.

Wang C et al. Cell Discov 2023 Apr 19;9(1):42

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:33511417 - Repression of a large number of genes requires interplay between homologous recombination and HIRA.

Misova I et al. Nucleic Acids Res 2021 Feb 26;49(4):1914-1934

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:9658169 - Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.

Radcliffe P et al. Mol Biol Cell 1998 Jul;9(7):1757-71

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:23028377 - Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

Choi ES et al. PLoS Genet 2012 Sep;8(9):e1002985

PMID:12773392 - Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.

Nakayama J et al. EMBO J 2003 Jun 02;22(11):2776-87

PMID:19164572 - Msc1 links dynamic Swi6/HP1 binding to cell fate determination.

Lawrence RJ et al. Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1163-8

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:25651869 - Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Doi A et al. Genes Cells 2015 Apr;20(4):292-309

PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.

Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237

PMID:37459529 - Class I histone deacetylase complex: Structure and functional correlates.

Wang X et al. Proc Natl Acad Sci U S A 2023 Jul 25;120(30):e2307598120

PMID:21211723 - Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Yamane K et al. Mol Cell 2011 Jan 07;41(1):56-66

PMID:17450151 - Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.

Nicolas E et al. Nat Struct Mol Biol 2007 May;14(5):372-80

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514