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protein coding gene - srb10 (SPAC23H4.17c) - mediator complex cyclin-dependent protein kinase subunit Srb10

Gene summary

Standard name
srb10
Systematic ID
SPAC23H4.17c
Product
mediator complex cyclin-dependent protein kinase subunit Srb10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
prk1, cdk8
UniProt ID
O13958
ORFeome ID
16/16C01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1576707..1578028 forward strand

Annotation

Disease association

MONDO:0030059 - developmental and epileptic encephalopathy, 87

References:

MONDO:0032897 - intellectual developmental disorder with hypotonia and behavioral abnormalities

References:

GO biological process

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0060261 - positive regulation of transcription initiation by RNA polymerase II

References:

GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

References:

GO:0000791 - euchromatin

References:

GO:0016592 - mediator complex

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GO molecular function

GO:0004693 - cyclin-dependent protein serine/threonine kinase activity

References:

GO:0140834 - RNA polymerase II CTD heptapeptide repeat S2 kinase activity

References:

GO:0140836 - RNA polymerase II CTD heptapeptide repeat S5 kinase activity

References:

GO:0003713 - transcription coactivator activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0003535 - decreased bipolar index

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0004357 - decreased protein phosphorylation during mitosis

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Genotypes:

FYPO:0002831 - delayed onset of protein phosphorylation during mitosis

References:

Genotypes:

FYPO:0000155 - increased flocculation

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Genotypes:

FYPO:0003532 - increased monopolar index

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

References:

Genotypes:

FYPO:0002619 - normal growth on sodium butyrate

References:

Genotypes:

FYPO:0002620 - normal growth on trichostatin A

References:

Genotypes:

FYPO:0000590 - normal sporulation

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPfam
cd07842STKc_CDK8_likeCDD
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE patterns
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE profiles
SM00220S_TKcProt_kinase_domSMART
G3DSA:1.10.510.10:FF:000408CATH-FunFam
G3DSA:1.10.510.10CATH-Gene3D
G3DSA:3.30.200.20CATH-Gene3D
SSF56112Kinase-like_dom_sfSUPERFAMILY
PTHR24056CDKPANTHER

Orthologs

References / Literature

PMID:28515143 - Cyclin C influences the timing of mitosis in fission yeast.
Banyai G et al. Mol Biol Cell 2017 Jul 01;28(13):1738-1744
PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.
Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.
Zhang L et al. PLoS One 2013;8(7):e68738
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:9559556 - Characterization of the Prk1 protein kinase from Schizosaccharomyces pombe.
Watson P et al. Yeast 1998 Mar 30;14(5):485-92
PMID:10625684 - Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.
Spåhr H et al. J Biol Chem 2000 Jan 14;275(2):1351-6
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:25154415 - Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.
Banyai G et al. Mol Cell Biol 2014 Nov;34(21):4008-18
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:9450029 - Loss of Prk1 leads to cell aggregation in the fission yeast Schizosaccharomyces pombe.
Watson P et al. Biochem Soc Trans 1997 Nov;25(4):S601
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:30294483 - LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast.
Park YD et al. Mycobiology 2018;46(3):236-241
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:26219431 - Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
Mühlbacher W et al. Proteins 2015 Oct;83(10):1849-58
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22451489 - Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.
Szilagyi Z et al. Mol Cell Biol 2012 Jun;32(11):2099-109
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.
Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7
PMID:23122962 - Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.
Drogat J et al. Cell Rep 2012 Nov 29;2(5):1068-76
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424