protein coding gene - sty1 (SPAC24B11.06c) - MAP kinase Sty1

Gene summary

Standard name

sty1

Systematic ID

SPAC24B11.06c

Product

MAP kinase Sty1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

spc1, phh1

UniProt ID

Q09892

ORFeome ID

16/16A05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 206476..208136 reverse strand

Annotation

Protein features

Orthologs

• MAPK11 (HGNC:6873) Homo sapiens
• MAPK12 (HGNC:6874) Homo sapiens
• MAPK13 (HGNC:6875) Homo sapiens
• MAPK14 (HGNC:6876) Homo sapiens
• sty1 (SJAG_02592) Schizosaccharomyces japonicus
• HOG1 (YLR113W) Saccharomyces cerevisiae

References / Literature

PMID:38499131 - The deletion of ppr2 interferes iron sensing and leads to oxidative stress response in Schizosaccharomyces pombe.

Liu Z et al. Mitochondrion 2024 Mar 16;:101875

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.

Martin SG et al. Nature 2009 Jun 11;459(7248):852-6

PMID:17919454 - Modulation of Spc1 stress-activated protein kinase activity by methylglyoxal through inhibition of protein phosphatase in the fission yeast Schizosaccharomyces pombe.

Takatsume Y et al. Biochem Biophys Res Commun 2007 Nov 30;363(4):942-7

PMID:11350071 - Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.

Jeong JH et al. Biochem Biophys Res Commun 2001 May 18;283(4):908-14

PMID:21801748 - Regulation of HMG-CoA reductase in mammals and yeast.

Burg JS et al. Prog Lipid Res 2011 Oct;50(4):403-10

PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.

Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46

PMID:10348908 - A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.

Ohmiya R et al. J Biochem 1999 Jun;125(6):1061-6

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25793410 - Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

Alao JP et al. PLoS One 2015;10(3):e0119297

PMID:21965528 - Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.

Hálová L et al. J Cell Sci 2011 Oct 15;124(Pt 20):3441-9

PMID:9251044 - Stress-activated protein kinase pathway in cell cycle control of fission yeast.

Shiozaki K et al. Methods Enzymol 1997;283:506-20

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:9199286 - Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe.

Sengar AS et al. Mol Cell Biol 1997 Jul;17(7):3508-19

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:23389634 - Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.

Morigasaki S et al. Mol Biol Cell 2013 Apr;24(7):1083-92

PMID:24155978 - Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2.

Kato T et al. PLoS One 2013;8(10):e78012

PMID:34731607 - Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.

Salat-Canela C et al. Cell Rep 2021 Nov 02;37(5):109951

PMID:19037094 - The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.

Garcia P et al. Mol Biol Cell 2009 Jan;20(2):721-31

PMID:32023460 - Plasma Membrane Furrows Control Plasticity of ER-PM Contacts.

Ng AQE et al. Cell Rep 2020 Feb 04;30(5):1434-1446.e7

PMID:9188094 - Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade.

Shiozaki K et al. Mol Biol Cell 1997 Mar;8(3):409-19

PMID:11751918 - The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Taricani L et al. J Biol Chem 2002 Mar 22;277(12):10562-72

PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

Weisman R et al. Genetics 2005 Feb;169(2):539-50

PMID:32075773 - Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress.

Cabrera M et al. Cell Rep 2020 Feb 18;30(7):2430-2443.e4

PMID:15840944 - Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe.

Yoshida J et al. Cell Struct Funct 2005 Feb;29(5-6):125-38

PMID:15225554 - A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase.

Veal EA et al. Mol Cell 2004 Jul 02;15(1):129-39

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:25963819 - Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Lucena R et al. J Cell Biol 2015 May 11;209(3):387-402

PMID:8824588 - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

Wilkinson MG et al. Genes Dev 1996 Sep 15;10(18):2289-301

PMID:15164362 - Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress.

Paredes V et al. Yeast 2004 May;21(7):593-603

PMID:15917811 - Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast.

Petersen J et al. Nature 2005 May 26;435(7041):507-12

PMID:12723602 - Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.

Nakamichi N et al. Biosci Biotechnol Biochem 2003 Mar;67(3):547-55

PMID:26567340 - Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P et al. J Biol Chem 2016 Jan 08;291(2):790-9

PMID:19723888 - Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay.

Alao JP et al. Mol Cancer Ther 2009 Sep;8(9):2606-15

PMID:33410907 - The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.

Wang YT et al. Nucleic Acids Res 2021 Jan 25;49(2):805-817

PMID:26108447 - Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast.

Hu L et al. Genes Cells 2015 Sep;20(9):695-705

PMID:33386485 - Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress.

Boronat S et al. Curr Genet 2021 Apr;67(2):237-243

PMID:24748152 - Fission yeast Rad52 phosphorylation restrains error prone recombination pathways.

Bellini A et al. PLoS One 2014;9(4):e95788

PMID:12715160 - The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Yang P et al. Mol Genet Genomics 2003 Apr;269(1):116-25

PMID:18272791 - Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.

López-Avilés S et al. Mol Biol Cell 2008 Apr;19(4):1670-9

PMID:18422613 - A novel gene, ecl1(+), extends the chronological lifespan in fission yeast.

Ohtsuka H et al. FEMS Yeast Res 2008 Jun;8(4):520-30

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:15448137 - Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.

Davidson MK et al. J Biol Chem 2004 Dec 03;279(49):50857-63

PMID:31911490 - RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.

Prieto-Ruiz F et al. mBio 2020 Jan 07;11(1)

PMID:9819443 - Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast.

Kon N et al. Mol Cell Biol 1998 Dec;18(12):7575-83

PMID:16914721 - Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Rodríguez-Gabriel MA et al. Mol Cell Biol 2006 Sep;26(17):6347-56

PMID:12861001 - Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.

Tatebe H et al. Mol Cell Biol 2003 Aug;23(15):5132-42

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:34157946 - TOR and MAP kinase pathways synergistically regulate autophagy in response to nutrient depletion in fission yeast.

Corral-Ramos C et al. Autophagy 2022 Feb;18(2):375-390

PMID:40716740 - TORC2 and MAPK signaling pathways regulate mitochondrial degradation induced by iron starvation in Schizosaccharomyces pombe.

Li R et al. J Biol Chem 2025 Jul 25;:110524

PMID:11886858 - The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast.

Sánchez-Piris M et al. J Biol Chem 2002 May 17;277(20):17722-7

PMID:30280012 - Crystal structure and functional analysis of human C1ORF123.

A Rahaman SN et al. PeerJ 2018;6:e5377

PMID:11004189 - Characterization of tpp1(+) as encoding a main trehalose-6P phosphatase in the fission yeast Schizosaccharomyces pombe.

Franco A et al. J Bacteriol 2000 Oct;182(20):5880-4

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:38523261 - MAPK-dependent control of mitotic progression in S. pombe.

Iglesias-Romero AB et al. BMC Biol 2024 Mar 25;22(1):71

PMID:23832353 - The fission yeast php2 mutant displays a lengthened chronological lifespan.

Takuma K et al. Biosci Biotechnol Biochem 2013;77(7):1548-55

PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.

Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:16603158 - The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein.

Wang LY et al. FEBS Lett 2006 May 01;580(10):2409-13

PMID:24224056 - The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.

Kato H et al. PLoS One 2013;8(11):e80572

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:26624998 - Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase-Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance.

Su Y et al. PLoS One 2015;10(12):e0143888

PMID:20075862 - Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Zuin A et al. EMBO J 2010 Mar 03;29(5):981-91

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:37572670 - A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms.

Cao M et al. Mol Cell 2023 Sep 07;83(17):3140-3154.e7

PMID:12073089 - Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Curr Genet 2002 May;41(2):82-8

PMID:12855726 - Different roles for the stress-activated protein kinase pathway in the regulation of trehalose metabolism in Schizosaccharomyces pombe.

Paredes V et al. Microbiology (Reading) 2003 Jul;149(Pt 7):1745-1752

PMID:26366556 - Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Převorovský M et al. PLoS One 2015;10(9):e0137820

PMID:9321395 - Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast.

Samejima I et al. EMBO J 1997 Oct 15;16(20):6162-70

PMID:32795531 - Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.

Sánchez-Mir L et al. J Mol Biol 2020 Sep 04;432(19):5430-5446

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81

PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.

Miki R et al. FEBS J 2008 Nov;275(21):5309-24

PMID:42030144 - Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.

Du XM et al. Proc Natl Acad Sci U S A 2026 Apr 28;123(17):e2532532123

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:12080074 - The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast.

Smith DA et al. J Biol Chem 2002 Sep 06;277(36):33411-21

PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86

PMID:17346842 - Yeast-based screening to identify modulators of G-protein signaling using uncontrolled cell division cycle by overexpression of Stm1.

Chung KS et al. J Biotechnol 2007 May 01;129(3):547-54

PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93

PMID:23294323 - The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.

Cadou A et al. Biol Cell 2013 Mar;105(3):129-48

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:9614178 - Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism.

Shiozaki K et al. Mol Biol Cell 1998 Jun;9(6):1339-49

PMID:9154834 - Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1997 Jun;17(6):3356-63

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:11460168 - A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast.

Gachet Y et al. Nature 2001 Jul 19;412(6844):352-5

PMID:31477575 - Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast.

Morigasaki S et al. J Cell Sci 2019 Oct 10;132(19)

PMID:23640764 - Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.

Jang YJ et al. Yeast 2013 Oct;30(10):379-94

PMID:18065650 - Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.

Asp E et al. Eukaryot Cell 2008 Feb;7(2):328-38

PMID:20919928 - Two-component mediated peroxide sensing and signal transduction in fission yeast.

Quinn J et al. Antioxid Redox Signal 2011 Jul 01;15(1):153-65

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:10233152 - Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast.

Gaits F et al. Mol Biol Cell 1999 May;10(5):1395-407

PMID:22144913 - Widespread cotranslational formation of protein complexes.

Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398

PMID:31601154 - gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe .

Imai Y et al. Biosci Biotechnol Biochem 2020 Feb;84(2):330-337

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:12787490 - Regulation of the gene encoding glutathione synthetase from the fission yeast.

Kim SJ et al. J Biochem Mol Biol 2003 May 31;36(3):326-31

PMID:8649397 - Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1996 Jun;16(6):2870-7

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:17369398 - A novel checkpoint mechanism regulating the G1/S transition.

Tvegård T et al. Genes Dev 2007 Mar 15;21(6):649-54

PMID:20453258 - Living on the edge: stress and activation of stress responses promote lifespan extension.

Zuin A et al. Aging (Albany NY) 2010 Apr;2(4):231-7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:39540318 - Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.

Moscoso-Romero E et al. Open Biol 2024 Nov;14(11):240101

PMID:31116668 - Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis.

Morris Z et al. Mol Biol Cell 2019 Jul 15;30(15):1791-1804

PMID:10954610 - The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Kim M et al. Nucleic Acids Res 2000 Sep 01;28(17):3392-402

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:34523683 - Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.

Rich-Robinson J et al. J Cell Sci 2021 Oct 01;134(19)

PMID:32071154 - Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.

Hsiao WY et al. Mol Cell Biol 2020 Apr 13;40(9)

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:28924043 - Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.

Opalko HE et al. J Biol Chem 2017 Nov 10;292(45):18457-18468

PMID:23118915 - Stress activated protein kinase pathway modulates homologous recombination in fission yeast.

Bellini A et al. PLoS One 2012;7(10):e47987

PMID:29900664 - Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway.

Hibi T et al. Genes Cells 2018 Jun 14;

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:42017229 - Temperature-specific regulation of the NDR kinase Orb6 by the MAPK Sty1 to promote heat stress resilience.

Doyle LP et al. J Cell Sci 2026 Apr 15;139(8)

PMID:28515144 - Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress.

Schutt KL et al. Mol Biol Cell 2017 Jul 01;28(13):1804-1814

PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42

PMID:19076239 - Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast.

Vashisht AA et al. FEMS Yeast Res 2009 Mar;9(2):257-69

PMID:12181336 - Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast.

Nguyen AN et al. Mol Biol Cell 2002 Aug;13(8):2651-63

PMID:16258244 - Characterization and regulation of the gene encoding monothiol glutaredoxin 3 in the fission yeast Schizosaccharomyces pombe.

Moon JS et al. Mol Cells 2005 Aug 31;20(1):74-82

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:8824587 - Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Shiozaki K et al. Genes Dev 1996 Sep 15;10(18):2276-88

PMID:15611161 - In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1.

Tang Y et al. Genetics 2004 Dec;168(4):1843-53

PMID:12684881 - A defect in a fatty acyl-CoA synthetase gene, lcf1+, results in a decrease in viability after entry into the stationary phase in fission yeast.

Oshiro T et al. Mol Genet Genomics 2003 Jul;269(4):437-42

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:12359231 - Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.

Lee J et al. Biochem Biophys Res Commun 2002 Oct 04;297(4):854-62

PMID:33225241 - The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.

Boronat S et al. iScience 2020 Nov 20;23(11):101725

PMID:10428959 - Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

Wilkinson MG et al. EMBO J 1999 Aug 02;18(15):4210-21

PMID:9718372 - Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.

Shieh JC et al. J Cell Sci 1998 Sep;111 ( Pt 18):2799-807

PMID:22139357 - H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.

Di Y et al. EMBO J 2012 Feb 01;31(3):563-75

PMID:39761853 - Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex.

Weeks AT et al. J Biol Chem 2025 Jan 04;:108156

PMID:36107819 - cAMP-Protein kinase A and stress-activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation.

Pérez-Díaz AJ et al. Autophagy 2023 Apr;19(4):1311-1331

PMID:20655879 - The MAP kinase Pmk1 and protein kinase A are required for rotenone resistance in the fission yeast, Schizosaccharomyces pombe.

Wang Y et al. Biochem Biophys Res Commun 2010 Aug 20;399(2):123-8

PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

Shieh JC et al. Genes Dev 1997 Apr 15;11(8):1008-22

PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:17881729 - Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.

Takada H et al. Mol Biol Cell 2007 Dec;18(12):4794-802

PMID:9450957 - The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.

Shieh JC et al. Mol Biol Cell 1998 Feb;9(2):311-22

PMID:11461899 - Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS et al. J Biol Chem 2001 Oct 26;276(43):40190-201

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:38289024 - Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.

Sun L et al. Elife 2024 Jan 30;13

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.

Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748

PMID:8557102 - Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

Kato T et al. FEBS Lett 1996 Jan 15;378(3):207-12

PMID:12896976 - Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.

Castillo EA et al. J Biol Chem 2003 Oct 17;278(42):40565-72

PMID:18406331 - Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade.

Morigasaki S et al. Mol Cell 2008 Apr 11;30(1):108-13

PMID:12221110 - Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Greenall A et al. Mol Biol Cell 2002 Sep;13(9):2977-89

PMID:17612531 - RNA-binding protein Csx1 is phosphorylated by LAMMER kinase, Lkh1, in response to oxidative stress in Schizosaccharomyces pombe.

Kang WH et al. FEBS Lett 2007 Jul 24;581(18):3473-8

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:14633985 - RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.

Rodríguez-Gabriel MA et al. EMBO J 2003 Dec 01;22(23):6256-66

PMID:23690545 - Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase.

Kowalczyk KM et al. J Cell Sci 2013 Aug 01;126(Pt 15):3324-32

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:12589433 - Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1.

Asp E et al. Mol Genet Genomics 2003 Feb;268(5):585-97

PMID:20444100 - Hyperosmosis enhances radiation and hydroxyurea resistance of Schizosaccharomyces pombe checkpoint mutants through the spindle checkpoint and delayed cytokinesis.

Alao JP et al. Mol Microbiol 2010 Jul 01;77(1):143-57

PMID:32269268 - Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.

Dong W et al. Sci Rep 2020 Apr 08;10(1):6055

PMID:16278445 - Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast.

Dunand-Sauthier I et al. Eukaryot Cell 2005 Nov;4(11):1785-93

PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.

Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308

PMID:9443913 - Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases.

Bone N et al. Curr Biol 1998 Jan 29;8(3):135-44

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:9560390 - Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.

Humphrey T et al. Genetics 1998 Apr;148(4):1731-42

PMID:31932483 - A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H 2 O 2 and Is the Target of a Small Molecule.

Sjölander JJ et al. Mol Cell Biol 2020 Mar 16;40(7)

PMID:9202173 - Osmo-stress-induced changes in neutral trehalase activity of the fission yeast Schizosaccharomyces pombe.

Fernández J et al. Biochim Biophys Acta 1997 Jun 05;1357(1):41-8

PMID:27664222 - A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.

He Y et al. Nucleic Acids Res 2017 Jan 09;45(1):106-114

PMID:15292231 - Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

Kim HS et al. J Biol Chem 2004 Oct 08;279(41):42850-9

PMID:22084378 - Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 2011 Dec 27;366(1584):3508-20

PMID:15936270 - Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.

Tatebe H et al. Curr Biol 2005 Jun 07;15(11):1006-15

PMID:20624911 - Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe.

Pöhlmann J et al. Mol Cell Biol 2010 Sep;30(18):4535-47

PMID:12383265 - Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe.

Soto T et al. Eur J Biochem 2002 Oct;269(20):5056-65

PMID:10940030 - Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator.

Aoyama K et al. J Bacteriol 2000 Sep;182(17):4868-74

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:10428498 - The cta3+ gene that encodes a cation-transporting P-type ATPase is induced by salt stress under control of the Wis1-Sty1 MAPKK-MAPK cascade in fission yeast.

Nishikawa T et al. FEBS Lett 1999 Jul 16;455(1-2):183-7

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:16087744 - Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.

Rodríguez-Gabriel MA et al. Eukaryot Cell 2005 Aug;4(8):1396-402

PMID:19279143 - Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.

Satoh R et al. Mol Biol Cell 2009 May;20(9):2473-85

PMID:15870269 - Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Wang LY et al. Mol Cell Biol 2005 May;25(10):3945-55

PMID:29065217 - The fission yeast MAPK Spc1 senses perturbations in Cdc25 and Wee1 activities and targets Rad24 to restore this balance.

Paul M et al. Yeast 2018 Mar;35(3):261-271

PMID:29146263 - Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe.

Kar P et al. Microbiol Res 2018 Jan;206:82-90

PMID:7657164 - Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

Millar JB et al. Genes Dev 1995 Sep 01;9(17):2117-30

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:10467003 - The pub1 E3 ubiquitin ligase negatively regulates leucine uptake in response to NH(4)(+) in fission yeast.

Karagiannis J et al. Curr Genet 1999 Jul;35(6):593-601

PMID:30236788 - Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.

Sanchez-Marinas M et al. Free Radic Biol Med 2018 Dec;129:116-126

PMID:28652406 - Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C et al. J Biol Chem 2017 Aug 18;292(33):13635-13644

PMID:39509469 - Rho1 and Rgf1 establish a new actin-dependent signal to determine growth poles in yeast independently of microtubules and the Tea1-Tea4 complex.

Garcia P et al. PLoS Biol 2024 Nov 07;22(11):e3002491

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:28799013 - Phospho-mimicking Atf1 mutants bypass the transcription activating function of the MAP kinase Sty1 of fission yeast.

Sánchez-Mir L et al. Curr Genet 2018 Feb;64(1):97-102

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94

PMID:20164182 - Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.

Soto T et al. J Biol Chem 2010 Apr 09;285(15):11516-25

PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.

Chua G et al. Genetics 2002 Oct;162(2):689-703

PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.

Larkin A et al. Dev Cell 2024 Jul 26;

PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42

PMID:26697385 - Genome wide transcription profiling of the effects of overexpression of Spc1 and its kinase dead mutant in Schizosaccharomyces pombe.

Paul M et al. Genom Data 2015 Dec;6:241-4

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:25803873 - Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.

Núñez A et al. PLoS One 2015;10(3):e0121059

PMID:27756188 - cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.

Matsuo Y et al. Biosci Biotechnol Biochem 2017 Feb;81(2):231-241

PMID:30318352 - A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth.

Haupt A et al. Curr Biol 2018 Oct 22;28(20):3342-3351.e3

PMID:23687372 - New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.

Martín R et al. J Cell Sci 2013 Jul 15;126(Pt 14):3010-20

PMID:38359013 - Correction: Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Převorovský M et al. PLoS One 2024;19(2):e0299200

PMID:26432170 - Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.

Vázquez B et al. Cell Signal 2015 Dec;27(12):2534-42

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:22912829 - Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.

Salgado A et al. PLoS One 2012;7(8):e43208

PMID:15358115 - Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe.

Chung WH et al. Biochem Biophys Res Commun 2004 Sep 03;321(4):922-9

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:30989357 - Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth.

Pérez P et al. Int Microbiol 2020 Jan;23(1):31-41

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:10398679 - Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases.

Nguyen AN et al. Genes Dev 1999 Jul 01;13(13):1653-63

PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Gómez-Gil E et al. Elife 2020 Sep 11;9

PMID:19436749 - Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast.

Gao J et al. PLoS One 2009;4(5):e5533

PMID:18003976 - Multiple pathways differentially regulate global oxidative stress responses in fission yeast.

Chen D et al. Mol Biol Cell 2008 Jan;19(1):308-17

PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51

PMID:24755092 - Cotranslational protein-RNA associations predict protein-protein interactions.

Duncan CD et al. BMC Genomics 2014 Apr 22;15:298

PMID:12135491 - Rum1, an inhibitor of cyclin-dependent kinase in fission yeast, is negatively regulated by mitogen-activated protein kinase-mediated phosphorylation at Ser and Thr residues.

Matsuoka K et al. Eur J Biochem 2002 Jul;269(14):3511-21

PMID:9585506 - Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast.

Gaits F et al. Genes Dev 1998 May 15;12(10):1464-73

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:38424265 - Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe.

Maekawa Y et al. Mol Genet Genomics 2024 Feb 29;299(1):20

PMID:9974219 - Enhancement of neutral trehalase activity by oxidative stress in the fission yeast Schizosaccharomyces pombe.

Fernández J et al. Fungal Genet Biol 1998 Nov;25(2):79-86

PMID:11179424 - Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Buck V et al. Mol Biol Cell 2001 Feb;12(2):407-19

PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24

PMID:10233158 - Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Rupes I et al. Mol Biol Cell 1999 May;10(5):1495-510

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:21098141 - Cellular stress induces cytoplasmic RNA granules in fission yeast.

Nilsson D et al. RNA 2011 Jan;17(1):120-33

PMID:20061379 - Hydrogen peroxide-sensitive cysteines in the Sty1 MAPK regulate the transcriptional response to oxidative stress.

Day AM et al. J Biol Chem 2010 Mar 05;285(10):7505-16

PMID:21869531 - Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation.

Gupta DR et al. Biosci Biotechnol Biochem 2011;75(8):1456-65

PMID:16861909 - Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.

Kawasaki Y et al. Cell Cycle 2006 Aug;5(16):1831-9

PMID:18062930 - Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX.

Jaendling A et al. Biochim Biophys Acta 2008 Feb;1783(2):203-13

PMID:9693384 - The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.

Samejima I et al. Mol Biol Cell 1998 Aug;9(8):2325-35

PMID:12063243 - Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe.

Veal EA et al. J Biol Chem 2002 Sep 20;277(38):35523-31

PMID:15135546 - Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast.

Hong SM et al. FEMS Microbiol Lett 2004 May 15;234(2):379-85

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:15629716 - Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.

López-Avilés S et al. Mol Cell 2005 Jan 07;17(1):49-59

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:37787465 - Glucose to lactate shift reprograms CDK-dependent mitotic decisions and its communication with MAPK Sty1 in Schizosaccharomyces pombe.

Sarkar P et al. Biol Open 2023 Oct 15;12(10)

PMID:23934882 - Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Viana RA et al. Genetics 2013 Oct;195(2):421-32

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

PMID:18235227 - Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Ikeda K et al. Cell Cycle 2008 Feb 01;7(3):358-64

PMID:22661707 - A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.

Zhou X et al. J Biol Chem 2012 Jul 06;287(28):23434-9

PMID:16141205 - The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

Zuin A et al. J Biol Chem 2005 Nov 04;280(44):36708-13

PMID:14665462 - Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.

Tanabe K et al. Eukaryot Cell 2003 Dec;2(6):1274-87

PMID:28775286 - Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNA Lys UUU modifications.

Villahermosa D et al. Sci Rep 2017 Aug 03;7(1):7225