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protein coding gene - mvd1 (SPAC24C9.03) - diphosphomevalonate decarboxylase mvd1

Gene summary

Standard name
mvd1
Systematic ID
SPAC24C9.03
Product
diphosphomevalonate decarboxylase mvd1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
erg19
UniProt ID
O13963
ORFeome ID
18/18G02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3041111..3043306 forward strand

Annotation

Disease association

MONDO:0013868 - porokeratosis 7, multiple types

References:

GO biological process

GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway

References:

GO:0045337 - trans, trans-farnesyl diphosphate biosynthetic process

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0004163 - diphosphomevalonate decarboxylase activity

References:

Modification

MOD:01149 - sumoylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003374 - normal cellular coenzyme Q10 level

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF18376MDD_CMvd1_CPfam
PF22700MVD-like_NMVD-like_NPfam
G3DSA:3.30.230.10:FF:000018CATH-FunFam
G3DSA:3.30.70.890:FF:000005CATH-FunFam
G3DSA:3.30.230.10Ribsml_uS5_D2-typ_fold_subgrCATH-Gene3D
G3DSA:3.30.70.890GHMP_kinase_C_sfCATH-Gene3D
SSF54211Ribosomal_Su5_D2-typ_SFSUPERFAMILY
SSF55060GHMP_kinase_C_sfSUPERFAMILY
PTHR10977PANTHER
PIRSF015950Mev_P_decrbxMev_decarbPIRSF
TIGR01240mevDPdecarbMev_diP_decarbNCBIFAM
CoilCOILS

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.
Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000033 - Annotation inferences using phylogenetic trees